دورية أكاديمية
أعرض في EDS

Sensory sensitivity to external stimuli in Tourette syndrome patients.

التفاصيل البيبلوغرافية
العنوان: Sensory sensitivity to external stimuli in Tourette syndrome patients.
المؤلفون: Belluscio BA; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1428, USA. belluscb@ninds.nih.gov, Jin L, Watters V, Lee TH, Hallett M
المصدر: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2011 Dec; Vol. 26 (14), pp. 2538-43. Date of Electronic Publication: 2011 Oct 28.
نوع المنشور: Journal Article; Research Support, N.I.H., Intramural
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8610688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8257 (Electronic) Linking ISSN: 08853185 NLM ISO Abbreviation: Mov Disord Subsets: MEDLINE
أسماء مطبوعة: Publication: <2001->: New York, NY : Wiley-Liss
Original Publication: [New York, N.Y.] : Raven Press, [c1986-
مواضيع طبية MeSH: Pain Threshold/*physiology , Sensory Thresholds/*physiology , Touch Perception/*physiology , Tourette Syndrome/*physiopathology, Adult ; Cognition/physiology ; Female ; Humans ; Male ; Middle Aged ; Olfactory Perception/physiology ; Physical Stimulation ; Tics/physiopathology ; Young Adult
مستخلص: Patients with Tourette Syndrome often state that their sensitivity to sensations is equally or more disruptive than are motor tics. However, their sensory sensitivity is not addressed by standard clinical assessments nor is it a focus of research. This lapse likely results from our limited awareness and understanding of the symptom. In this study (1) we defined the patients' experience of sensitivity to external stimuli in detail, and (2) we tested 2 hypotheses regarding its origin. First, we interviewed in depth and administered a lengthy questionnaire to adult Tourette patients (n = 19) and age-matched healthy volunteers (n = 19). Eighty percent of patients described heightened sensitivity to external stimuli, with examples among all 5 sensory modalities. Bothersome stimuli were characterized as faint, repetitive or constant, and nonsalient, whereas intense stimuli were well tolerated. We then determined whether the sensitivity could be the result of an increased ability to detect faint stimuli. After measuring the threshold of detection for olfactory and tactile stimuli among the patients and healthy volunteers, we found no significant differences between them for either sensory modality. These results indicate that patients' perceived sensitivity derives from altered central processing rather than enhanced peripheral detection. Last, we assessed one aspect of processing: the perception of intensity. When subjects rated the intensity of near-threshold tactile and olfactory stimuli, there was a surprising difference: Tourette patients more frequently used the lowest range of the scale than did healthy volunteers. Future research is necessary to define the anatomical and physiological basis of the patients' experience of heightened sensitivity. © 2011 Movement Disorder Society.
(Copyright © 2011 Movement Disorder Society.)
References: Mov Disord. 2003 Dec;18(12):1530-3. (PMID: 14673893)
Pract Neurol. 2010 Oct;10(5):252-9. (PMID: 20858626)
Neuron. 2000 Nov;28(2):349-54. (PMID: 11144345)
Biol Psychiatry. 2009 Apr 1;65(7):594-9. (PMID: 19111281)
Chem Senses. 1997 Feb;22(1):39-52. (PMID: 9056084)
Neuroimage. 2001 Apr;13(4):547-60. (PMID: 11305885)
Neurology. 2005 Oct 25;65(8):1253-8. (PMID: 16247053)
Laryngoscope. 2007 Jan;117(1):114-20. (PMID: 17202939)
Curr Neurol Neurosci Rep. 2010 Jul;10(4):286-91. (PMID: 20446061)
Pediatr Rev. 2010 Jun;31(6):223-33. (PMID: 20516234)
Neurology. 1989 May;39(5):731-4. (PMID: 2710364)
Mov Disord. 2011 May;26(6):1149-56. (PMID: 21484868)
Am J Occup Ther. 2001 Jan-Feb;55(1):75-82. (PMID: 11216370)
Physiol Behav. 2004 Aug;82(1):109-14. (PMID: 15234598)
Int J Gynaecol Obstet. 2007 Apr;97(1):10-4. (PMID: 17335824)
Psychiatr Clin North Am. 2010 Sep;33(3):641-55. (PMID: 20599138)
J Dev Behav Pediatr. 2005 Dec;26(6):397-403. (PMID: 16344654)
J Neurol Neurosurg Psychiatry. 1997 Feb;62(2):188-92. (PMID: 9048721)
Pediatr Neurol. 2001 Sep;25(3):190-8. (PMID: 11587872)
Br J Math Stat Psychol. 1965 May;18:1-10. (PMID: 14324842)
J Am Acad Child Adolesc Psychiatry. 1994 Jul-Aug;33(6):805-8. (PMID: 8083137)
Biol Psychiatry. 1996 Jan 1;39(1):33-41. (PMID: 8719124)
J Child Adolesc Psychopharmacol. 2010 Aug;20(4):237-47. (PMID: 20807062)
J Clin Psychiatry. 1992 Sep;53(9):319-23. (PMID: 1517194)
J Child Neurol. 2006 Aug;21(8):678-89. (PMID: 16970869)
J Clin Psychiatry. 1995 Jun;56(6):246-55. (PMID: 7775367)
Biol Psychiatry. 2001 Oct 15;50(8):578-85. (PMID: 11690592)
N Engl J Med. 2010 Dec 9;363(24):2332-8. (PMID: 21142535)
Am J Psychiatry. 1993 Jan;150(1):98-102. (PMID: 8417589)
Curr Opin Neurol. 2011 Apr;24(2):119-25. (PMID: 21386676)
Arch Gen Psychiatry. 1980 Dec;37(12):1343-7. (PMID: 6934713)
معلومات مُعتمدة: Z01 NS003031 United States ImNIH Intramural NIH HHS; Z01 NS003031-01 United States ImNIH Intramural NIH HHS; Z99 NS999999 United States ImNIH Intramural NIH HHS
تواريخ الأحداث: Date Created: 20111101 Date Completed: 20120228 Latest Revision: 20240608
رمز التحديث: 20240608
مُعرف محوري في PubMed: PMC3240739
DOI: 10.1002/mds.23977
PMID: 22038938
قاعدة البيانات: MEDLINE
الوصف
تدمد:1531-8257
DOI:10.1002/mds.23977