دورية أكاديمية
Ficus platyphylla promotes fertility in female Rattus norvegicus Wistar strain: a preliminary study.
| العنوان: | Ficus platyphylla promotes fertility in female Rattus norvegicus Wistar strain: a preliminary study. |
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| المؤلفون: | Ugwah-Oguejiofor CJ; Department of Pharmacology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University Sokoto, Nigeria. nenye789@yahoo.com, Bello SO, Okolo RU, Etuk EU, Ugwah MO, Igbokwe VU |
| المصدر: | Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2011 Nov 02; Vol. 9, pp. 145. Date of Electronic Publication: 2011 Nov 02. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101153627 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-7827 (Electronic) Linking ISSN: 14777827 NLM ISO Abbreviation: Reprod Biol Endocrinol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, 2003- |
| مواضيع طبية MeSH: | Fertility/*drug effects , Ficus/*chemistry , Plant Extracts/*pharmacology , Reproduction/*drug effects, Analysis of Variance ; Animals ; Animals, Newborn ; Dose-Response Relationship, Drug ; Embryo Implantation/drug effects ; Female ; Litter Size/drug effects ; Male ; Random Allocation ; Rats ; Rats, Wistar ; Time Factors ; Treatment Outcome |
| مستخلص: | Background: Ficus platyphylla Delile (family-Moracea) commonly called gutta percha tree is a deciduous plant found in savannah areas. It grows widely in the Northern part of Nigeria, up to 60 ft. high and is known as 'gamji' by the Hausas. The seeds, bark and leaves have been used traditionally in combination to promote fertility. Scientifically, the plant has been shown to have analgesic, anti-inflammatory and CNS effects. The present study was to validate the use of this plant to promote fertility in female Rattus norvegicus Wistar strain using various fertility parameters. Methods: Female Rattus norvegicus Wistar strain weighing between 150-180 g were randomly selected and divided into two major groups. Each group was subdivided into 5 treatment groups of 100, 200, 400 mg/kg BW of aqueous extract of F. platyphylla and a control group of 5 ml/kg of distilled water. A positive control of clomiphene citrate was used. Treatment of the first group was discontinued after 15 days prior to mating (pre-mating treatment group), while the other was treated continuously till delivery (continuous treatment group). At the 10th day, females were sacrificed and implantation sites were checked and embryos counted. Upon delivery, litter sizes were determined and the pups weighed and checked for deformities. Other reproductive indices were calculated. Data were analyzed by one-way analysis of variance and students T-test. Proportions were analysed by Chi square. Statistical evaluations were performed using STATS programs and Graphpad prism, and a difference was considered statistically significant at P < 0.05. Results: There was a significant reduction in the percentage post implantation losses of both the pre-treatment and the continuous treatment groups when compared to their distil water controls. The litter size of the pre-treatment group was similar to the distil water group while at 400 mg/kg, the continuous treatment group showed an increase in the litter size similar to that of the clomiphene group. There were no observed external deformities in the pups. Conclusions: Administration of aqueous extract of F. platyphylla promotes fertility by reducing post implantation loss and by increasing litter size in female Rattus norvegicus Wistar strain. |
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| المشرفين على المادة: | 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20111104 Date Completed: 20120328 Latest Revision: 20240317 |
| رمز التحديث: | 20240317 |
| مُعرف محوري في PubMed: | PMC3222613 |
| DOI: | 10.1186/1477-7827-9-145 |
| PMID: | 22046966 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1477-7827 |
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| DOI: | 10.1186/1477-7827-9-145 |