دورية أكاديمية
Xenotropic murine leukemia virus-related virus does not pose a risk to blood recipient safety.
| العنوان: | Xenotropic murine leukemia virus-related virus does not pose a risk to blood recipient safety. |
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| المؤلفون: | Dodd RY; American Red Cross Holland Laboratory, Rockville, Maryland 20855, USA. dodd@usa.redcross.org, Hackett J Jr, Linnen JM, Dorsey K, Wu Y, Zou S, Qiu X, Swanson P, Schochetman G, Gao K, Carrick JM, Krysztof DE, Stramer SL |
| المصدر: | Transfusion [Transfusion] 2012 Feb; Vol. 52 (2), pp. 298-306. Date of Electronic Publication: 2011 Nov 21. |
| نوع المنشور: | Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association Of Blood Banks Country of Publication: United States NLM ID: 0417360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-2995 (Electronic) Linking ISSN: 00411132 NLM ISO Abbreviation: Transfusion Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Arlington, Va. : American Association Of Blood Banks |
| مواضيع طبية MeSH: | Blood Safety*/methods, Retroviridae Infections/*blood , Retroviridae Infections/*transmission , Xenotropic murine leukemia virus-related virus/*physiology, Adolescent ; Adult ; Blood Donors/statistics & numerical data ; Blood Specimen Collection/methods ; Blood Specimen Collection/standards ; Blood Specimen Collection/statistics & numerical data ; Fatigue Syndrome, Chronic/blood ; Fatigue Syndrome, Chronic/epidemiology ; Fatigue Syndrome, Chronic/etiology ; Fatigue Syndrome, Chronic/virology ; Female ; Humans ; Male ; Middle Aged ; RNA, Viral/blood ; RNA, Viral/isolation & purification ; Retroviridae Infections/epidemiology ; Retroviridae Infections/virology ; Risk Factors ; Serologic Tests ; Transplantation/physiology ; Transplantation/statistics & numerical data ; Xenotropic murine leukemia virus-related virus/genetics ; Xenotropic murine leukemia virus-related virus/isolation & purification |
| مستخلص: | Background: When xenotropic murine leukemia virus-related virus (XMRV) was first reported in association with chronic fatigue syndrome, it was suggested that it might offer a risk to blood safety. Thus, the prevalence of the virus among blood donors and, if present, its transmissibility by transfusion need to be defined. Study Design and Methods: Two populations of routine blood donor samples (1435 and 13,399) were obtained for prevalence evaluations; samples from a linked donor-recipient repository were also evaluated. Samples were tested for the presence of antibodies to XMRV-related recombinant antigens and/or for XMRV RNA, using validated, high-throughput systems. Results: The presence of antibodies to XMRV could not be confirmed among a total of 17,249 blood donors or recipients (0%; 95% confidence interval [CI], 0%-0.017%); 1763 tested samples were nonreactive for XMRV RNA (0%; 95% CI, 0%-0.17%). Evidence of infection was absent from 109 recipients and 830 evaluable blood samples tested after transfusion of a total of 3741 blood components. Conclusions: XMRV and related murine leukemia virus (MLV) markers are not present among a large population of blood donors and evidence of transfusion transmission could not be detected. Thus, these viruses do not currently pose a threat to blood recipient safety and further actions relating to XMRV and MLV are not justified. (© 2012 American Association of Blood Banks.) |
| المشرفين على المادة: | 0 (RNA, Viral) |
| تواريخ الأحداث: | Date Created: 20111122 Date Completed: 20120305 Latest Revision: 20220930 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/j.1537-2995.2011.03450.x |
| PMID: | 22098340 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-2995 |
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| DOI: | 10.1111/j.1537-2995.2011.03450.x |