دورية أكاديمية
أعرض في EDS

Rab28 function in trypanosomes: interactions with retromer and ESCRT pathways.

التفاصيل البيبلوغرافية
العنوان: Rab28 function in trypanosomes: interactions with retromer and ESCRT pathways.
المؤلفون: Lumb JH; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK., Leung KF, Dubois KN, Field MC
المصدر: Journal of cell science [J Cell Sci] 2011 Nov 15; Vol. 124 (Pt 22), pp. 3771-83. Date of Electronic Publication: 2011 Nov 18.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: Cambridge : Company of Biologists
Original Publication: London.
مواضيع طبية MeSH: Endosomal Sorting Complexes Required for Transport/*metabolism , Endosomes/*metabolism , Protozoan Proteins/*metabolism , Trypanosoma brucei brucei/*metabolism , rab GTP-Binding Proteins/*metabolism, Endosomal Sorting Complexes Required for Transport/genetics ; Endosomes/genetics ; Protein Binding ; Protozoan Proteins/genetics ; Trypanosoma brucei brucei/genetics ; Vesicular Transport Proteins/genetics ; Vesicular Transport Proteins/metabolism ; rab GTP-Binding Proteins/genetics
مستخلص: Early endosomal cargo is typically targeted to either a degradative or recycling pathway. Despite established functions for the retromer and ESCRT complexes at late endosomes/multivesicular bodies, the mechanisms integrating and coordinating these functions remain largely unknown. Rab family GTPases are key membrane trafficking organizers and could contribute. Here, in the unicellular organism Trypanosoma brucei, we demonstrate that Rab28 locates to the endosomal pathway and partially colocalizes with Vps23, an ESCRT I component. Rab28 is required for turnover of endocytosed proteins and for lysosomal delivery of protein cargo. Using RNA interference we find that in Rab28-depleted cells, protein levels of ESCRT I (Vps23/28) and retromer (Vps26) are also decreased, suggesting that Rab28 is an important regulator of these factors. We suggest that Rab28 coordinates the activity of retromer-dependent trafficking and ESCRT-mediated degradative pathways.
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معلومات مُعتمدة: United Kingdom WT_ Wellcome Trust; 082813/Z/07/Z United Kingdom WT_ Wellcome Trust; 09007/Z/09/Z United Kingdom WT_ Wellcome Trust; United Kingdom MRC_ Medical Research Council
المشرفين على المادة: 0 (Endosomal Sorting Complexes Required for Transport)
0 (Protozoan Proteins)
0 (Vesicular Transport Proteins)
EC 3.6.5.2 (rab GTP-Binding Proteins)
تواريخ الأحداث: Date Created: 20111122 Date Completed: 20120402 Latest Revision: 20240627
رمز التحديث: 20240627
مُعرف محوري في PubMed: PMC3225266
DOI: 10.1242/jcs.079178
PMID: 22100919
قاعدة البيانات: MEDLINE
الوصف
تدمد:1477-9137
DOI:10.1242/jcs.079178