دورية أكاديمية
Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization.
| العنوان: | Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization. |
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| المؤلفون: | Kripke ML; Department of Immunology, University of Texas M. D. Anderson Cancer Center, Houston 77030., Munn CG, Jeevan A, Tang JM, Bucana C |
| المصدر: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 1990 Nov 01; Vol. 145 (9), pp. 2833-8. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print Cited Medium: Print ISSN: 0022-1767 (Print) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Bethesda, MD : American Association of Immunologists Original Publication: Baltimore : Williams & Wilkins, c1950- |
| مواضيع طبية MeSH: | Antigen-Presenting Cells/*immunology , Dermatitis, Contact/*immunology , Lymph Nodes/*cytology , Skin/*immunology, Animals ; Antigen-Presenting Cells/physiology ; Cell Movement ; Cell Separation ; Flow Cytometry ; Langerhans Cells/immunology ; Langerhans Cells/ultrastructure ; Lymph Nodes/immunology ; Major Histocompatibility Complex ; Mice ; Mice, Inbred Strains ; Microscopy, Electron |
| مستخلص: | These studies address the hypothesis that Ag-bearing epidermal Langerhans cells migrate to the regional lymph node during contact sensitization and function as APC. Skin from C3H mice was grafted onto BALB/c nude mice, and 7 or 14 days later, the recipients were sensitized with FITC through the grafts. APC from lymph nodes draining the site of sensitization were capable of sensitizing C3H recipients to FITC. Because sensitization is MHC restricted, only cells reaching the lymph node from the grafted skin could have induced contact hypersensitivity in C3H mice. Examination of the FITC+ draining lymph node cells by immunofluorescence and immunoelectron microscopy demonstrated that all were Ia+, most were F4/80+, and some contained Birbeck granules. These studies demonstrate that Ia+, FITC+ cells from the skin, at least some of which are Langerhans cells, leave the skin after epicutaneous sensitization with FITC and participate in the initiation of the contact hypersensitivity response within the regional lymph node. |
| معلومات مُعتمدة: | R01-CA44713 United States CA NCI NIH HHS |
| تواريخ الأحداث: | Date Created: 19901101 Date Completed: 19901121 Latest Revision: 20071114 |
| رمز التحديث: | 20221213 |
| PMID: | 2212665 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0022-1767 |
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