دورية أكاديمية
أعرض في EDS

Heritability of volumetric brain changes and height in children entering puberty.

التفاصيل البيبلوغرافية
العنوان: Heritability of volumetric brain changes and height in children entering puberty.
المؤلفون: van Soelen IL; Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands. I.vanSoelen@umcutrecht.nl, Brouwer RM, van Baal GC, Schnack HG, Peper JS, Chen L, Kahn RS, Boomsma DI, Hulshoff Pol HE
المصدر: Human brain mapping [Hum Brain Mapp] 2013 Mar; Vol. 34 (3), pp. 713-25. Date of Electronic Publication: 2011 Dec 03.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Twin Study
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 9419065 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0193 (Electronic) Linking ISSN: 10659471 NLM ISO Abbreviation: Hum Brain Mapp Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Wiley
Original Publication: New York : Wiley-Liss, c1993-
مواضيع طبية MeSH: Models, Genetic*, Body Height/*genetics , Brain/*anatomy & histology , Brain/*growth & development , Child Development/*physiology, Brain Mapping ; Child ; Confidence Intervals ; Female ; Humans ; Image Processing, Computer-Assisted ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Multivariate Analysis ; Twins, Dizygotic ; Twins, Monozygotic
مستخلص: The human brain undergoes structural changes in children entering puberty, while simultaneously children increase in height. It is not known if brain changes are under genetic control, and whether they are related to genetic factors influencing the amount of overall increase in height. Twins underwent magnetic resonance imaging brain scans at age 9 (N = 190) and 12 (N = 125). High heritability estimates were found at both ages for height and brain volumes (49-96%), and high genetic correlation between ages were observed (r(g) > 0.89). With increasing age, whole brain (+1.1%), cerebellum (+4.2%), cerebral white matter (+5.1%), and lateral ventricle (+9.4%) volumes increased, and third ventricle (-4.0%) and cerebral gray matter (-1.6%) volumes decreased. Children increased on average 13.8 cm in height (9.9%). Genetic influences on individual difference in volumetric brain and height changes were estimated, both within and across traits. The same genetic factors influenced both cerebral (20% heritable) and cerebellar volumetric changes (45%). Thus, the extent to which changes in cerebral and cerebellar volumes are heritable in children entering puberty are due to the same genes that influence change in both structures. The increase in height was heritable (73%), and not associated with cerebral volumetric change, but positively associated with cerebellar volume change (r(p) = 0.24). This association was explained by a genetic correlation (r(g) = 0.48) between height and cerebellar change. Brain and body each expand at their own pace and through separate genetic pathways. There are distinct genetic processes acting on structural brain development, which cannot be explained by genetic increase in height.
(Copyright © 2011 Wiley Periodicals, Inc.)
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تواريخ الأحداث: Date Created: 20111206 Date Completed: 20130829 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6870442
DOI: 10.1002/hbm.21468
PMID: 22140022
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-0193
DOI:10.1002/hbm.21468