دورية أكاديمية
Impact of subclinical hypothyroidism treatment in systolic and diastolic cardiac function.
| العنوان: | Impact of subclinical hypothyroidism treatment in systolic and diastolic cardiac function. |
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| المؤلفون: | Martins RM; Endocrinology Service, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro., Fonseca RH, Duarte MM, Reuters VS, Ferreira MM, Almeida C, Buescu A, Teixeira Pde F, Vaisman M |
| المصدر: | Arquivos brasileiros de endocrinologia e metabologia [Arq Bras Endocrinol Metabol] 2011 Oct; Vol. 55 (7), pp. 460-7. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sociedade Brasileira de Endocrinologia e Metabologia Country of Publication: Brazil NLM ID: 0403437 Publication Model: Print Cited Medium: Internet ISSN: 1677-9487 (Electronic) Linking ISSN: 00042730 NLM ISO Abbreviation: Arq Bras Endocrinol Metabol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Rio de Janeiro : Sociedade Brasileira de Endocrinologia e Metabologia |
| مواضيع طبية MeSH: | Heart/*drug effects , Hormone Replacement Therapy/*adverse effects , Hypothyroidism/*physiopathology , Thyroxine/*adverse effects, Adult ; Cardiac Output/drug effects ; Cardiac Output/physiology ; Diastole/drug effects ; Double-Blind Method ; Female ; Heart/physiopathology ; Humans ; Hypothyroidism/diagnostic imaging ; Hypothyroidism/drug therapy ; Middle Aged ; Statistics, Nonparametric ; Systole/drug effects ; Thyroxine/therapeutic use ; Treatment Outcome ; Ultrasonography ; Ventricular Function, Left/drug effects |
| مستخلص: | Objective: To evaluate the effects of levothyroxine (L-T4) replacement in echocardiographic parameters of middle-aged women with subclinical hypothyroidism (SH). Subjects and Methods: This was a randomized, double-blind, placebo-controlled study. Echocardiographic evaluation was carried out at baseline and one year after restoration of euthyroidism. Thirty-three women with SH were assigned to one of two groups (L-T4 or placebo). Results: The two groups had similar basal characteristics. There was a significant deterioration of left ventricular Tei index after one year of placebo use, which differed from the effect of L-T4 replacement (+0.086 ± 0.092 vs. -0.014 ± 0.012; p = 0.047). There was also a slight reduction in cardiac output and cardiac index with placebo use, which was not different from L-T4 effect. Conclusion: Results suggest a positive impact of L-T4 replacement in cardiac function of middle-aged women with SH. |
| التعليقات: | Erratum in: Arq Bras Endocrinol Metabol. 2012 Feb;56(1):74-6. |
| المشرفين على المادة: | Q51BO43MG4 (Thyroxine) |
| تواريخ الأحداث: | Date Created: 20111208 Date Completed: 20120711 Latest Revision: 20220410 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1590/s0004-27302011000700005 |
| PMID: | 22147094 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1677-9487 |
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| DOI: | 10.1590/s0004-27302011000700005 |