دورية أكاديمية
Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats.
| العنوان: | Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats. |
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| المؤلفون: | Lobato NS; Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil., Filgueira FP, Hagihara GN, Akamine EH, Pariz JR, Tostes RC, Carvalho MH, Fortes ZB |
| المصدر: | Life sciences [Life Sci] 2012 Jan 30; Vol. 90 (5-6), pp. 228-35. Date of Electronic Publication: 2011 Nov 29. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2008->: Amsterdam : Elsevier Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press. |
| مواضيع طبية MeSH: | Hypoglycemic Agents/*administration & dosage , Mesenteric Arteries/*metabolism , Metformin/*administration & dosage , Nitric Oxide Synthase/*metabolism , Obesity/*drug therapy, Acetylcholine/pharmacology ; Animals ; Blood Pressure/drug effects ; Body Weight/drug effects ; Disease Models, Animal ; Dyslipidemias/drug therapy ; Epoprostenol/metabolism ; Hyperinsulinism/drug therapy ; Indomethacin/pharmacology ; Insulin/blood ; Insulin Resistance ; Male ; Mesenteric Arteries/drug effects ; Nitric Oxide/analysis ; Nitric Oxide/metabolism ; Nitric Oxide Synthase/analysis ; Nitroprusside/pharmacology ; Norepinephrine/pharmacology ; Obesity/chemically induced ; Obesity/physiopathology ; Rats ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Sodium Glutamate/administration & dosage ; Thromboxane A2/metabolism |
| مستخلص: | Aims: Metformin is an insulin sensitizing agent with beneficial effects in diabetic patients on glycemic levels and in the cardiovascular system. We examined whether the metabolic changes and the vascular dysfunction in monosodium glutamate-induced obese non-diabetic (MSG) rats might be improved by metformin. Main Methods: 16 week-old MSG rats were treated with metformin for 15 days and compared with age-matched untreated MSG and non-obese non-diabetic rats (control). Blood pressure, insulin sensitivity, vascular reactivity and prostanoid release in the perfused mesenteric arteriolar bed as well as nitric oxide production and reactive oxygen species generation in isolated mesenteric arteries were analyzed. Key Findings: 18-week-old MSG rats displayed higher Lee index, fat accumulation, dyslipidemia, insulin resistance and hyperinsulinemia. Metformin treatment improved these alterations. The norepinephrine-induced response, increased in the mesenteric arteriolar bed from MSG rats, was corrected by metformin. Indomethacin corrected the enhanced contractile response in MSG rats but did not affect metformin effects. The sensitivity to acetylcholine, reduced in MSG rats, was also corrected by metformin. Indomethacin corrected the reduced sensitivity to acetylcholine in MSG rats but did not affect metformin effects. The sensitivity to sodium nitroprusside was increased in preparations from metformin-treated rats. Metformin treatment restored both the reduced PGI2/TXA2 ratio and the increased reactive oxygen species generation in preparations from MSG rats. Significance: Metformin improved the vascular function in MSG rats through reduction in reactive oxygen species generation, modulation of membrane hyperpolarization, correction of the unbalanced prostanoids release and increase in the sensitivity of the smooth muscle to nitric oxide. (Copyright © 2011 Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 0 (Hypoglycemic Agents) 0 (Insulin) 0 (Reactive Oxygen Species) 169D1260KM (Nitroprusside) 31C4KY9ESH (Nitric Oxide) 57576-52-0 (Thromboxane A2) 9100L32L2N (Metformin) DCR9Z582X0 (Epoprostenol) EC 1.14.13.39 (Nitric Oxide Synthase) N9YNS0M02X (Acetylcholine) W81N5U6R6U (Sodium Glutamate) X4W3ENH1CV (Norepinephrine) XXE1CET956 (Indomethacin) |
| تواريخ الأحداث: | Date Created: 20111214 Date Completed: 20120404 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.lfs.2011.11.005 |
| PMID: | 22154980 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0631 |
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| DOI: | 10.1016/j.lfs.2011.11.005 |