دورية أكاديمية
Folk uses and pharmacological properties of Casearia sylvestris: a medicinal review.
| العنوان: | Folk uses and pharmacological properties of Casearia sylvestris: a medicinal review. |
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| المؤلفون: | Ferreira PM; Departamento de Ciências Biológicas, Campus Senador Helvídio Nunes de Barros, Universidade Federal do Piauí, Picos, Brasil., Costa-Lotufo LV, Moraes MO, Barros FW, Martins AM, Cavalheiro AJ, Bolzani VS, Santos AG, Pessoa C |
| المصدر: | Anais da Academia Brasileira de Ciencias [An Acad Bras Cienc] 2011 Dec; Vol. 83 (4), pp. 1373-84. Date of Electronic Publication: 2011 Oct 07. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academia Brasileira De Ciencias Country of Publication: Brazil NLM ID: 7503280 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-2690 (Electronic) Linking ISSN: 00013765 NLM ISO Abbreviation: An Acad Bras Cienc Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Rio De Janeiro : Academia Brasileira De Ciencias |
| مواضيع طبية MeSH: | Anti-Inflammatory Agents/*pharmacology , Anti-Ulcer Agents/*pharmacology , Antidotes/*pharmacology , Antineoplastic Agents, Phytogenic/*pharmacology , Casearia/*chemistry , Plant Extracts/*pharmacology , Plant Oils/*pharmacology, Animals ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/isolation & purification ; Anti-Ulcer Agents/chemistry ; Anti-Ulcer Agents/isolation & purification ; Antidotes/chemistry ; Antidotes/isolation & purification ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Humans ; Medicine, Traditional ; Plant Extracts/chemistry ; Plant Leaves/chemistry ; Plant Oils/chemistry |
| مستخلص: | Folk uses and scientific investigations have highlighted the importance of Casearia sylvestris extracts and their relevant bioactive potential. The aim of this work was to review the pharmacological properties of C. sylvestris, emphasizing its anti-ulcer, anti-inflammatory, anti-ophidian and antitumor potentialities. Ethanolic extracts and essential oil of their leaves have antiulcerogenic activity and reduce gastric volume without altering the stomach pH, which corroborates their consumption on gastrointestinal disorders. Leaf water extracts show phospholipase A(2) inhibitory activity that prevents damage effects on the muscular tissue after toxin inoculation. This antiphospholipasic action is probably related to the use as an anti-inflammatory, proposing a pharmacological blockage similar to that obtained with non-steroidal anti-inflammatory drugs on arachidonic acid and cyclooxygenase pathways. Bioguided-assay fractionations lead to the identification of secondary metabolites, especially the clerodane diterpenes casearins (A-X) and casearvestrins (A-C), compounds with a remarkable cytotoxic and antitumor action. Therefore, the C. sylvestris shrub holds a known worldwide pharmacological arsenal by its extensive folk utilization, exciting searches for new molecules and a better comprehension about biological properties. |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (Anti-Ulcer Agents) 0 (Antidotes) 0 (Antineoplastic Agents, Phytogenic) 0 (Plant Extracts) 0 (Plant Oils) |
| تواريخ الأحداث: | Date Created: 20111214 Date Completed: 20120927 Latest Revision: 20191112 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1590/s0001-37652011005000040 |
| PMID: | 22159347 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1678-2690 |
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| DOI: | 10.1590/s0001-37652011005000040 |