دورية أكاديمية
[Comparative experimental study of antioxidant efficiency in treatment of acute pancreatitis].
| العنوان: | [Comparative experimental study of antioxidant efficiency in treatment of acute pancreatitis]. |
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| المؤلفون: | Kliuĭko DA, Korik VE, Zhidkov SA |
| المصدر: | Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2011; Vol. 74 (9), pp. 11-5. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izd-vo Meditsina Country of Publication: Russia (Federation) NLM ID: 9215981 Publication Model: Print Cited Medium: Print ISSN: 0869-2092 (Print) Linking ISSN: 08692092 NLM ISO Abbreviation: Eksp Klin Farmakol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Izd-vo Meditsina |
| مواضيع طبية MeSH: | Antioxidants/*therapeutic use , Flavin Mononucleotide/*therapeutic use , Inosine Diphosphate/*therapeutic use , Niacinamide/*therapeutic use , Pancreas/*drug effects , Pancreatitis/*drug therapy , Picolines/*therapeutic use , Succinates/*therapeutic use, Acute Disease ; Animals ; Antioxidants/administration & dosage ; Disease Models, Animal ; Drug Combinations ; Flavin Mononucleotide/administration & dosage ; Guinea Pigs ; Injections, Intraperitoneal ; Inosine Diphosphate/administration & dosage ; Niacinamide/administration & dosage ; Oxygen/analysis ; Oxygen Consumption/drug effects ; Pancreas/metabolism ; Pancreatitis/metabolism ; Partial Pressure ; Picolines/administration & dosage ; Succinates/administration & dosage ; Treatment Outcome |
| مستخلص: | The aims of our experiments on animals were (i) to evaluate by direct oximery the efficiency of various antioxidant drugs in a complex treatment of acute pancreatitis and (ii) to determine the diagnostic value of the direct oximetry method for estimation of the efficiency of medical treatment. The article presents data obtained in a group 75 outbred Guinea with a model acute pancreatitis, which were treated with mexibel (group 1), emoxipin (group 2), end cytoflavin (group 3), with subsequent investigation of the pancreatic tissues by the direct oximetry method. The obtained results confirmed that the intraperitoneal injection of cytoflavin to animals stimulates tissue respiration, improves metabolism, promotes pancreas recovery, and also improves the prognosis and reduces the lethal outcome. The efficiency of cytoflavin within the complex therapy exceeds the effect of other antioxidants (mexibel and emoxipin) under otherwise equal conditions. |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Drug Combinations) 0 (Picolines) 0 (Succinates) 0 (cytoflavin) 25X51I8RD4 (Niacinamide) 2R985002CT (emoxypine succinate) 7N464URE7E (Flavin Mononucleotide) 86-04-4 (Inosine Diphosphate) S88TT14065 (Oxygen) V247P5H4E1 (6-methyl-2-ethyl-3-hydroxypyridine) |
| تواريخ الأحداث: | Date Created: 20111215 Date Completed: 20120130 Latest Revision: 20161125 |
| رمز التحديث: | 20221213 |
| PMID: | 22164440 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0869-2092 |
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