دورية أكاديمية
Pulmonary arterial hypertension in systemic sclerosis is associated with profound impairment of microvascular endothelium-dependent vasodilatation.
| العنوان: | Pulmonary arterial hypertension in systemic sclerosis is associated with profound impairment of microvascular endothelium-dependent vasodilatation. |
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| المؤلفون: | Hofstee HM; Department of Internal Medicine, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. hma.hofstee@vumc.nl, Voskuyl AE, Vonk Noordegraaf A, Smulders YM, Postmus PE, Dijkmans BA, Serné EH |
| المصدر: | The Journal of rheumatology [J Rheumatol] 2012 Jan; Vol. 39 (1), pp. 100-5. Date of Electronic Publication: 2011 Dec 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Journal Of Rheumatology Publishing Co Country of Publication: Canada NLM ID: 7501984 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0315-162X (Print) Linking ISSN: 0315162X NLM ISO Abbreviation: J Rheumatol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Toronto : Journal Of Rheumatology Publishing Co Original Publication: Toronto. |
| مواضيع طبية MeSH: | Endothelium, Vascular/*physiopathology , Hypertension, Pulmonary/*physiopathology , Microcirculation/*drug effects , Scleroderma, Systemic/*physiopathology , Vasodilation/*drug effects , Vasodilator Agents/*pharmacology, Acetylcholine/pharmacology ; Adult ; Aged ; Cardiac Catheterization ; Endothelium, Vascular/drug effects ; Familial Primary Pulmonary Hypertension ; Female ; Humans ; Iontophoresis ; Laser-Doppler Flowmetry ; Microcirculation/physiology ; Middle Aged ; Nitroprusside/pharmacology |
| مستخلص: | Objective: Impaired microvascular function may contribute to organ complications in patients with systemic sclerosis (SSc). We investigated whether SSc patients with and without pulmonary arterial hypertension (PAH) show a graded impairment of microvascular function compared to healthy controls. Methods: Twenty-two patients with SSc and 22 controls were studied. All patients underwent right heart catheterization; 6 had no PAH (SSc-nonPAH) and 16 had PAH (SSc-PAH). Acetylcholine (ACh)-mediated endothelium-dependent vasodilatation and sodium nitroprusside (SNP)-mediated endothelium-independent vasodilatation were assessed by iontophoresis combined with laser Doppler flowmetry. Results: Compared to sex- and age-matched controls, ACh-mediated vasodilatation was reduced in SSc-PAH (340.4% vs 79.5%, respectively; p < 0.01), but not in SSc-nonPAH (340.4% vs 397.9%; p = 0.90). No significant differences were present between the groups in SNP-mediated vasodilatation. Conclusion: Systemic microvascular endothelium-dependent vasodilatation is markedly reduced in SSc complicated by PAH. |
| المشرفين على المادة: | 0 (Vasodilator Agents) 169D1260KM (Nitroprusside) N9YNS0M02X (Acetylcholine) |
| تواريخ الأحداث: | Date Created: 20111217 Date Completed: 20120501 Latest Revision: 20141120 |
| رمز التحديث: | 20221213 |
| DOI: | 10.3899/jrheum.110397 |
| PMID: | 22174212 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0315-162X |
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| DOI: | 10.3899/jrheum.110397 |