دورية أكاديمية
أعرض في EDS

Effects of intra-ventrolateral periaqueductal grey palmitoylethanolamide on thermoceptive threshold and rostral ventromedial medulla cell activity.

التفاصيل البيبلوغرافية
العنوان: Effects of intra-ventrolateral periaqueductal grey palmitoylethanolamide on thermoceptive threshold and rostral ventromedial medulla cell activity.
المؤلفون: de Novellis V; Endocannabinoid Research Group at the Department of Experimental Medicine, Division of Pharmacology 'L. Donatelli', The Second University of Naples, 80138 Naples, Italy., Luongo L, Guida F, Cristino L, Palazzo E, Russo R, Marabese I, D'Agostino G, Calignano A, Rossi F, Di Marzo V, Maione S
المصدر: European journal of pharmacology [Eur J Pharmacol] 2012 Feb 15; Vol. 676 (1-3), pp. 41-50. Date of Electronic Publication: 2011 Dec 03.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : Amsterdam : Elsevier Science
Original Publication: Amsterdam, North Holland Pub. Co.
مواضيع طبية MeSH: Temperature*, Analgesics/*pharmacology , Myelencephalon/*cytology , Neurons/*drug effects , Nociception/*drug effects , Palmitic Acids/*pharmacology , Periaqueductal Gray/*drug effects, Amides ; Animals ; Behavior, Animal/drug effects ; Endocannabinoids ; Ethanolamines ; Gene Expression Regulation/drug effects ; Male ; Myelencephalon/drug effects ; Myelencephalon/metabolism ; Neurons/cytology ; Neurons/metabolism ; PPAR alpha/antagonists & inhibitors ; PPAR alpha/metabolism ; Potassium Channels, Calcium-Activated/antagonists & inhibitors ; Rats ; Rats, Wistar ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; TRPV Cation Channels/antagonists & inhibitors
مستخلص: Palmitoylethanolamide (PEA), a peroxisome proliferator-activated receptor-α (PPAR-α) ligand, exerts antinociceptive and anti-inflammatory effects. PEA (3 and 6 nmol) was microinjected in the ventrolateral periaqueductal grey (VL PAG) of male rats and effects on nociceptive responses and ongoing and tail flick-related activities of rostral ventromedial medulla (RVM) ON and OFF cells were recorded. Intra-PAG microinjection of PEA reduced the ongoing activity of ON and OFF cells and produced an increase in the latency of the nociceptive reaction. These effects were prevented by a selective PPAR-α antagonist, GW6471 and by a large-conductance Ca(2+)-activated K(+) channel inhibitor, charybdotoxin. Cannabinoid 1 (CB(1)) receptor blockade by AM251 increased the PEA-induced effect both on the ongoing activity of the ON cell and on the latency to tail flick without affecting the effect of PEA on the OFF cell. Conversely, a transient receptor potential vanilloid type 1 (TRPV(1)) blocker, I-RTX, had no effect on the ON cell activity and tail flick latency, whereas it blocked the PEA-induced decrease in ongoing activity of the OFF cell. PEA decreased the burst and increased the latency of tail flick-evoked onset of ON cell activity in a manner antagonised by GW6471 and charybdotoxin. AM251 and I-RTX, instead, enhanced these latter effects. In conclusion, intra-VL PAG PEA induces antinociceptive effects associated with a decrease in RVM ON and OFF cell activities. PPAR-α receptors mediate, and CB(1) and TRPV(1) receptors antagonise, PEA-induced effects within the PAG-RVM circuitry.
(Copyright © 2011 Elsevier B.V. All rights reserved.)
المشرفين على المادة: 0 (Amides)
0 (Analgesics)
0 (Endocannabinoids)
0 (Ethanolamines)
0 (PPAR alpha)
0 (Palmitic Acids)
0 (Potassium Channels, Calcium-Activated)
0 (Receptor, Cannabinoid, CB1)
0 (TRPV Cation Channels)
0 (TRPV1 receptor)
6R8T1UDM3V (palmidrol)
تواريخ الأحداث: Date Created: 20111220 Date Completed: 20120518 Latest Revision: 20201209
رمز التحديث: 20240628
DOI: 10.1016/j.ejphar.2011.11.034
PMID: 22178921
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0712
DOI:10.1016/j.ejphar.2011.11.034