دورية أكاديمية
أعرض في EDS

Acute promyelocytic leukemia associated with the PLZF-RARA fusion gene: two additional cases with clinical and laboratorial peculiar presentations.

التفاصيل البيبلوغرافية
العنوان: Acute promyelocytic leukemia associated with the PLZF-RARA fusion gene: two additional cases with clinical and laboratorial peculiar presentations.
المؤلفون: Rohr SS; Disciplina de Hematologia e Hemoterapia, UNIFESP, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu, 740-3.andar, São Paulo, SP, CEP 04023-900, Brazil. sandra.rohr@gmail.com, Pelloso LA, Borgo A, De Nadai LC, Yamamoto M, Rego EM, de Lourdes L F Chauffaille M
المصدر: Medical oncology (Northwood, London, England) [Med Oncol] 2012 Dec; Vol. 29 (4), pp. 2345-7. Date of Electronic Publication: 2011 Dec 29.
نوع المنشور: Case Reports; Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : New York : Springer
Original Publication: Northwood, Middlesex, England : Science and Technology Letters, c1994-
مواضيع طبية MeSH: Leukemia, Promyelocytic, Acute/*genetics , Oncogene Proteins, Fusion/*genetics, Adult ; Chromosomes, Human, Pair 11 ; Chromosomes, Human, Pair 17 ; Female ; Humans ; Male ; Middle Aged ; Translocation, Genetic
مستخلص: Acute promyelocytic leukemia (APL) is characterized by the presence of the t(15;17) and PML-RARa rearrangement, with good response to treatment with retinoids. However, few cases of variant APL involving alternative chromosomal aberrations have been reported, including t(11;17)(q23;q21) (Wells et al. in Nat Genet 17:109-113, 1; Arnould et al. in Hum Mol Genet 8:1741-1749, 2) t(5;17)(q35;q12-21), t(11;17)(q13;q21) (Grimwade et al in Blood 96:1297-1308, 3) and der(17) (Rego et al. in Blood (ASH Annual Meeting Abstracts)114:Abstract 6, 4), whereby RARa is fused to the PLZF, NPM, NuMA, and STAT5b genes, respectively, have been described. These cases are characterized by distinct morphology, clinical presentation, and in respect to PLZF, a lack of differentiation response to retinoids leading to the need of different approaches concerning diagnostic methods and therapeutics. This paper describes two cases of APL associated with the PLZF-RARA fusion gene enrolled in the IC-APL trial that is a non-randomized, multicenter study conducted in Brazil, Mexico, Chile and Uruguay with the aim to improve the treatment outcome of APL patients in developing countries. These cases, although rare, offer a challenge to its early recognition and proper conduction.
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المشرفين على المادة: 0 (Oncogene Proteins, Fusion)
0 (PLZF-RARalpha fusion protein, human)
تواريخ الأحداث: Date Created: 20111230 Date Completed: 20130726 Latest Revision: 20220408
رمز التحديث: 20240628
DOI: 10.1007/s12032-011-0147-y
PMID: 22205181
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-131X
DOI:10.1007/s12032-011-0147-y