دورية أكاديمية
Anti-tumorigenic activity of sophoflavescenol against Lewis lung carcinoma in vitro and in vivo.
| العنوان: | Anti-tumorigenic activity of sophoflavescenol against Lewis lung carcinoma in vitro and in vivo. |
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| المؤلفون: | Jung HA; Department of Food Science and Human Nutrition, Chonbuk National University, Jeonju, 561-756, Korea., Jin SE, Choi RJ, Manh HT, Kim YS, Min BS, Son YK, Ahn BR, Kim BW, Sohn HS, Choi JS |
| المصدر: | Archives of pharmacal research [Arch Pharm Res] 2011 Dec; Vol. 34 (12), pp. 2087-99. Date of Electronic Publication: 2011 Dec 31. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pharmaceutical Society of Korea Country of Publication: Korea (South) NLM ID: 8000036 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1976-3786 (Electronic) Linking ISSN: 02536269 NLM ISO Abbreviation: Arch Pharm Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Seoul, Pharmaceutical Society of Korea. |
| مواضيع طبية MeSH: | Antineoplastic Agents, Phytogenic/*isolation & purification , Antineoplastic Agents, Phytogenic/*therapeutic use , Carcinoma, Lewis Lung/*drug therapy , Flavonoids/*isolation & purification , Flavonoids/*therapeutic use , Sophora/*chemistry, Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Cell Line, Tumor ; Female ; Flavonoids/pharmacology ; Free Radical Scavengers/isolation & purification ; Free Radical Scavengers/pharmacology ; Free Radical Scavengers/therapeutic use ; Humans ; Male ; Mice ; Mice, Inbred ICR ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Roots/chemistry ; Rats |
| مستخلص: | This study examined the in vitro cytotoxic activity and in vivo antitumor activity as well as intracellular apoptotic capacities of a prenylated flavonol, sophoflavescenol from Sophora flavescens, to evaluate prospective anti-tumorigenic drugs, and antitumor potential. In addition, the in vitro antioxidant and anti-inflammatory capacities were evaluated. Despite the small effect on human breast adenocarcinoma (MCF-7), sophoflavescenol showed cytotoxicity against human leukaemia (HL-60), Lewis lung carcinoma (LLC), and human lung adenocarcinoma epithelial (A549) cells. Interestingly, it also exerted potent in vivo antitumor activity by tumor growth inhibition in the LLC tumor model as well as apoptotic activity by caspase-3 activation in HL-60 cells. In addition, it exhibited potent antioxidant activities in 1,1-diphenyl-2-picrylhydrazyl, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt radicals and lipid peroxidation assays. Sophoflavescenol exerted notable anti-inflammatory activity by inhibiting nitric oxide generation and tert-butylhydroperoxide-induced ROS generation rather than inhibiting nuclear factor kappa B activation in RAW 264.7 cells. The findings show that the antioxidant, anti-inflammatory, and apoptotic activities of sophoflavescenol might contribute to the antitumor activity without severe side effects, highlighting its potential for chemoprevention and/or anticancer drugs due to multi-effective targets in almost all stages of tumorigenesis, including initiation, promotion, and progression. |
| المشرفين على المادة: | 0 (Antineoplastic Agents, Phytogenic) 0 (Flavonoids) 0 (Free Radical Scavengers) 0 (Plant Extracts) 0 (sophoflavescenol) |
| تواريخ الأحداث: | Date Created: 20120103 Date Completed: 20120823 Latest Revision: 20120102 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s12272-011-1212-y |
| PMID: | 22210035 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1976-3786 |
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| DOI: | 10.1007/s12272-011-1212-y |