دورية أكاديمية
أعرض في EDS

Prevalence of Trypanosoma cruzi antibodies and inflammatory markers in uncompensated heart failure.

التفاصيل البيبلوغرافية
العنوان: Prevalence of Trypanosoma cruzi antibodies and inflammatory markers in uncompensated heart failure.
المؤلفون: Bravo Tobar I; Unidade de Bioquímica, Decanato de Ciencias de la Salud, Universidade Centro-Occidental Lisandro Alvarado Barquisimeto, Estado Lara, Venezuela., Parra F, Nello Pérez C, Rodríguez-Bonfante C, Useche F, Bonfante-Cabarcas R
المصدر: Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2011 Nov-Dec; Vol. 44 (6), pp. 691-6.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Sociedade Brasileira de Medicina Tropical Country of Publication: Brazil NLM ID: 7507456 Publication Model: Print Cited Medium: Internet ISSN: 1678-9849 (Electronic) Linking ISSN: 00378682 NLM ISO Abbreviation: Rev Soc Bras Med Trop Subsets: MEDLINE
أسماء مطبوعة: Publication: <1997-> : Uberaba, MG, Brazil : Sociedade Brasileira de Medicina Tropical
Original Publication: Rio De Janeiro : Sociedade Brasileira De Medicina Tropical
مواضيع طبية MeSH: Antibodies, Protozoan/*blood , Chagas Cardiomyopathy/*immunology , Heart Failure/*parasitology , Trypanosoma cruzi/*immunology, Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; C-Reactive Protein/analysis ; Chagas Cardiomyopathy/complications ; Chagas Cardiomyopathy/epidemiology ; Chronic Disease ; Cytokines/blood ; Electrocardiography ; Enzyme-Linked Immunosorbent Assay ; Epidemiologic Methods ; Female ; Heart Failure/blood ; Humans ; Male ; Middle Aged ; Rural Population ; Venezuela/epidemiology ; Young Adult
مستخلص: Introduction: Heart failure (HF) represents the final stage of chronic chagasic cardiomyopathy (CChC). The diagnosis of CChC is based on the demonstration of anti-Trypanosoma cruzi antibodies (aTcAg) and clinical and epidemiological data. In Venezuela, there are no data about the prevalence of chagasic HF. The aim of this study was to determine the epidemiological, clinical, and inflammatory risk factors associated with seronegative or seropositive HF patients.
Methods: We performed a cross-sectional study in the Venezuelan central-west states among a healthy rural population and in patients admitted to the emergency room with uncompensated HF.
Results: The seroprevalence rates of Trypanosoma cruzi antibodies were 11.2% and 40.1% in the healthy population and in HF patients, respectively. Seropositivity in healthy individuals was associated with age, knowledge on triatomine vectors, and having seen wild reservoirs in the house; in HF patients, with contact with the vector and previous clinical diagnosis of Chagas' disease; and in both groups taken together, with age, knowledge on triatomines, and HF. Seropositive patients had prolonged QRS, decreased ejection fraction, and high serum magnesium, all significant as compared with HF seronegative cases. Left atrium enlargement and ventricular hypertrophy were most frequently observed in HF seronegative patients. CRP, IL6, ILβ1, IL2, and FNTα were elevated in 94.5%, 48%, 17.8%, 13.7%, and 6.9% of HF patients, respectively, but only IL2 levels were associated with chagasic HF.
Conclusions: There is a high prevalence of aTcAg in HF patients from the central-west region of Venezuela, and their epidemiological, clinical, and inflammatory features are discreetly different as compared with those of seronegative cases.
المشرفين على المادة: 0 (Antibodies, Protozoan)
0 (Biomarkers)
0 (Cytokines)
9007-41-4 (C-Reactive Protein)
تواريخ الأحداث: Date Created: 20120111 Date Completed: 20120927 Latest Revision: 20190907
رمز التحديث: 20231215
DOI: 10.1590/s0037-86822011000600008
PMID: 22231242
قاعدة البيانات: MEDLINE
الوصف
تدمد:1678-9849
DOI:10.1590/s0037-86822011000600008