دورية أكاديمية
Evaluation of laboratory markers of progression of HIV disease to death.
| العنوان: | Evaluation of laboratory markers of progression of HIV disease to death. |
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| المؤلفون: | Viana GM; Departamento de Patologia, Universidade Federal do Maranhão, São Luis, MA, Brasil. gracaviana@globo.com, Nascimento Mdo D, Ferreira Ade M, Rabelo ÉM, Diniz Neto JA, Galvão Cde S, Santos AC, Santos Júnior OM, Oliveira RA, Binda Júnior JR |
| المصدر: | Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2011 Nov-Dec; Vol. 44 (6), pp. 657-60. Date of Electronic Publication: 2011 Nov 23. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sociedade Brasileira de Medicina Tropical Country of Publication: Brazil NLM ID: 7507456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-9849 (Electronic) Linking ISSN: 00378682 NLM ISO Abbreviation: Rev Soc Bras Med Trop Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <1997-> : Uberaba, MG, Brazil : Sociedade Brasileira de Medicina Tropical Original Publication: Rio De Janeiro : Sociedade Brasileira De Medicina Tropical |
| مواضيع طبية MeSH: | Disease Progression* , Viral Load*, Alanine Transaminase/*blood , Aspartate Aminotransferases/*blood , HIV Infections/*mortality , Hemoglobin A/*metabolism, Adult ; Biomarkers/blood ; CD4 Lymphocyte Count ; Female ; HIV Infections/blood ; HIV Infections/immunology ; Humans ; Male ; Prognosis ; Retrospective Studies ; Survival Analysis ; Young Adult |
| مستخلص: | Introduction: One of the important current problems in HIV/AIDS infection is the establishment of epidemiological and laboratorial prognostic parameters during patient follow-up. This study aimed at analyzing the evolution of laboratory tests: CD4 lymphocyte count, viral load, hemoglobin (Hb), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the epidemiological variables sex and age as prognostic factors for survival in progression to death among AIDS patients. Methods: A retrospective study was conducted using analysis of medical records, and prospective 24-month follow-up of patients with HIV/ AIDS attended at the President Vargas Hospital Outpatient Clinic, a reference center in HIV/AIDS attendance in the State of Maranhão, Brazil. The study analyzed patients aged 10 to 60 years old, who manifested AIDS and who were not using antiretroviral therapy or had used it for less than 5 years. The Chi-square test was used for statistical analysis. Results: The sample included 100 patients--57 were current outpatients, and 43 had died. The variables viral load (p=0.726), ALT (p=0.314), sex (p=0.687), and age (p=0.742) were analyzed, and no evidence of association between them and worst prognosis was observed. Conclusions: A significant relation was verified between low Hb levels (p=0.000) and CD4 (p=0.000) and shorter survival. |
| المشرفين على المادة: | 0 (Biomarkers) 9034-51-9 (Hemoglobin A) EC 2.6.1.1 (Aspartate Aminotransferases) EC 2.6.1.2 (Alanine Transaminase) |
| تواريخ الأحداث: | Date Created: 20120112 Date Completed: 20120927 Latest Revision: 20190907 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1590/s0037-86822011005000062 |
| PMID: | 22234355 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1678-9849 |
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| DOI: | 10.1590/s0037-86822011005000062 |