دورية أكاديمية
أعرض في EDS

Deletion of the α immunoglobulin chain membrane-anchoring region reduces but does not abolish IgA secretion.

التفاصيل البيبلوغرافية
العنوان: Deletion of the α immunoglobulin chain membrane-anchoring region reduces but does not abolish IgA secretion.
المؤلفون: Amin R; Université de Limoges, CNRS, UMR7276, Contrôle des Réponses Immunes B et Lymphoproliférations, Limoges, France. rada.amin@etu.unilim.fr, Carrion C, Decourt C, Pinaud E, Cogné M
المصدر: Immunology [Immunology] 2012 May; Vol. 136 (1), pp. 54-63.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 0374672 Publication Model: Print Cited Medium: Internet ISSN: 1365-2567 (Electronic) Linking ISSN: 00192805 NLM ISO Abbreviation: Immunology Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Blackwell Scientific Publications
مواضيع طبية MeSH: Cell Membrane/*immunology , Immunoglobulin alpha-Chains/*immunology, Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Cell Differentiation ; Cell Lineage ; Cell Polarity ; Immunoglobulin alpha-Chains/genetics ; Lipopolysaccharides/immunology ; Mice ; Receptors, Antigen, B-Cell/immunology ; Transforming Growth Factor beta/immunology
مستخلص: Class switching and plasma cell differentiation occur at a high level within all mucosa-associated lymphoid tissues. The different classes of membrane immunoglobulin heavy chains are associated with the Igα/Igβ heterodimer within the B-cell receptor (BCR). Whether BCR isotypes convey specific signals adapted to the corresponding differentiation stages remains debated but IgG and IgA membranes have been suggested to promote plasma cell differentiation. We investigated the impact of blocking expression of the IgA-class BCR through a 'αΔtail' targeted mutation, deleting the Cα immunoglobulin gene membrane exon. This allowed us to evaluate to what extent class switching and plasma cell differentiation can be concurrent processes, allowing some αΔtail(+/+) B cells with an IgM BCR to directly differentiate into IgA plasma cells and yield serum secreted IgA in spite of the absence of membrane IgA(+) B lymphocytes. By contrast, in secretions the secretory IgA was very low, indicating that J-chain-positive plasma cells producing secretory IgA overwhelmingly differentiate from previously class-switched membrane IgA(+) memory B cells. In addition, although mucosa-associated lymphoid tissues are a major site for plasma cell accumulation, αΔtail(+/+) mice showed that the gut B-cell lineage homeostasis is not polarized toward plasma cell differentiation through a specific influence of the membrane IgA BCR.
(Published 2012. This article is a U.S. Government work and is in the public domain in the USA.)
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المشرفين على المادة: 0 (Immunoglobulin alpha-Chains)
0 (Lipopolysaccharides)
0 (Receptors, Antigen, B-Cell)
0 (Transforming Growth Factor beta)
تواريخ الأحداث: Date Created: 20120119 Date Completed: 20120516 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3372757
DOI: 10.1111/j.1365-2567.2012.03557.x
PMID: 22250990
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2567
DOI:10.1111/j.1365-2567.2012.03557.x