دورية أكاديمية
[Effects of a Cetraria islandica extract in monotherapy and in association with magnesium in an experimental-induced hepatopathy model].
| العنوان: | [Effects of a Cetraria islandica extract in monotherapy and in association with magnesium in an experimental-induced hepatopathy model]. |
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| عنوان ترانسليتريتد: | Efectele unui extract din Cetraria islandica în monoterapie şi în asociere cu magneziul pe un model de hepatopatie indusă experimental. |
| المؤلفون: | Cernescu IT; Universităţii de Medicină şi Farmacie 'Gr. T. Popa' Iaşi., Tarţău L, Macavei A, Lupuşoru CE |
| المصدر: | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi [Rev Med Chir Soc Med Nat Iasi] 2011 Oct-Dec; Vol. 115 (4), pp. 1195-9. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Romanian; Moldavian; Moldovan |
| بيانات الدورية: | Publisher: Societatii De Medici Si Naturalisti Country of Publication: Romania NLM ID: 0413735 Publication Model: Print Cited Medium: Print ISSN: 0048-7848 (Print) Linking ISSN: 00487848 NLM ISO Abbreviation: Rev Med Chir Soc Med Nat Iasi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Iasi : Societatii De Medici Si Naturalisti Original Publication: Iaşi. |
| مواضيع طبية MeSH: | Lichens* , Phytotherapy*, Antioxidants/*pharmacology , Liver Diseases/*drug therapy , Magnesium/*administration & dosage , Plant Extracts/*pharmacology, Alanine Transaminase/blood ; Animals ; Aspartate Aminotransferases/blood ; Bilirubin/blood ; Biomarkers/blood ; Cholesterol, HDL/blood ; Complement System Proteins/metabolism ; Disease Models, Animal ; Liver Diseases/blood ; Liver Diseases/diagnosis ; Neutrophils/cytology ; Rats ; Rats, Wistar ; Transaminases/blood ; Treatment Outcome |
| مستخلص: | Aim: To investigate the effects of a Cetraria islandica extract in an animal model of hepatopathy. Material and Methods: The experiments were carried out on Wistar rats, treated intraperitoneally (excepting carbon tetrachloride which was administered orally by esogastric tube), at single daily dose, for 28 days and divided in eight groups of 6 rats each: Group 1: Saline solution (0.5ml/100g bw/day); Group 2: MgSO4 (5mg/kbw/day); Group 3: C. islandica (Ci) extract (21.56mg/kbw/day); Group 4: Ci+MgSO4; Group 5: carbon tetrachloride (CT).(0.1 ml/100g bw/day); Group 6: CT+MgSO4; Group 7: CT+Ci; Group 8: CT+Ci+MgSO4. At the end of the experiment blood samples were taken to assess the effects on the blood parameters,TGO, TGP, GGT, LDH, serum total billirubin, neutrophil phagocytic function (Nitroblue tetrazolium test) and serum complement activity. This parameters were determined with VITROS 750 XRC device, using Johnson&Johnson kits. The results were statistically processed with the help of "t-Student" test. p<0.05 was considered statistically significant. Results: In this carbon tetrachloride-induced hepatopathy animal model, C. islandica extract demonstrated hepatoprotective and immuno-stimulating effects (proved by normalization of glutamic-pyruvic transminase, glutamic-oxalocetic transminase, serum total billirubin, stimulation of neutrophils percentage and phagocytic functions, decreasing the carbon tetrachloride-induced basophilia and monocytosis, especially in association with magnesium). Conclusions: Further studies are required to confirm the benefits of this association in hepatoprotective and immunomodulating therapies. |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Biomarkers) 0 (Cholesterol, HDL) 0 (Plant Extracts) 9007-36-7 (Complement System Proteins) EC 2.6.1.- (Transaminases) EC 2.6.1.1 (Aspartate Aminotransferases) EC 2.6.1.2 (Alanine Transaminase) I38ZP9992A (Magnesium) RFM9X3LJ49 (Bilirubin) |
| تواريخ الأحداث: | Date Created: 20120127 Date Completed: 20120325 Latest Revision: 20151119 |
| رمز التحديث: | 20221213 |
| PMID: | 22276469 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0048-7848 |
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