التفاصيل البيبلوغرافية
| العنوان: |
[Relationship of epidermal growth factor receptor in lung development]. |
| المؤلفون: |
Li HJ; Gansu Agricultural University, Lanzhou, China. lihj8805963@126.com, Liu Y, Hao HS, DU WH, Zhao XM, Wang D, Qin T, Ma YJ, Zhu HB |
| المصدر: |
Yi chuan = Hereditas [Yi Chuan] 2012 Jan; Vol. 34 (1), pp. 27-32. |
| نوع المنشور: |
Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: |
Chinese |
| بيانات الدورية: |
Publisher: Ke xue chu ban she Country of Publication: China NLM ID: 9436478 Publication Model: Print Cited Medium: Print ISSN: 0253-9772 (Print) Linking ISSN: 02539772 NLM ISO Abbreviation: Yi Chuan Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Beijing : Ke xue chu ban she, |
| مواضيع طبية MeSH: |
Signal Transduction*, ErbB Receptors/*metabolism , Lung/*growth & development , Lung Neoplasms/*metabolism, Animals ; ErbB Receptors/genetics ; Gene Expression Regulation ; Humans ; Lung/metabolism ; Lung Neoplasms/genetics ; Lung Neoplasms/physiopathology |
| مستخلص: |
The epidermal growth factor receptor (EGFR), a transmembrane protein receptor, is a member of ErbB family with signal-transducing tyrosine kinase activity. After combined with the ligand, EGFR homologous or heterologous dimers are formed to induce intracellular signal transduction, activate downstream signal transduction pathways, and then produce a series of biological effects. RAF/MEK/RAS/ERK pathway is relevant to cell proliferation, differentiation and apoptosis; while PDK1/AKT /PI3K pathway is involved in cell migration and adhesion. EGFR can promote the maturity of pulmonary type II epithelial cells and the synthesis and secretion of pulmonary surfactant. EGFR shows the effect on mammal lungs in a time-space and dose-dependent manner. The down-regulated expression of it will lead to immature lung development, while the over-expression can promote the cell proliferation, invasion and metastasis of the lung cancer cells. This paper reviewed advances in the study for EGFR and its signal pathway, as well as the relationship among EGFR, atelectasis and lung cancer. |
| المشرفين على المادة: |
EC 2.7.10.1 (ErbB Receptors) |
| تواريخ الأحداث: |
Date Created: 20120207 Date Completed: 20120327 Latest Revision: 20190923 |
| رمز التحديث: |
20221213 |
| DOI: |
10.3724/sp.j.1005.2012.00027 |
| PMID: |
22306870 |
| قاعدة البيانات: |
MEDLINE |
