دورية أكاديمية
أعرض في EDS

Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.

التفاصيل البيبلوغرافية
العنوان: Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.
المؤلفون: Guerrerio AL; Division of Pediatric Gastroenterology and Nutrition, Johns Hopkins School of Medicine, Baltimore, MD, USA., Colvin RM, Schwartz AK, Molleston JP, Murray KF, Diehl A, Mohan P, Schwimmer JB, Lavine JE, Torbenson MS, Scheimann AO
المصدر: The American journal of clinical nutrition [Am J Clin Nutr] 2012 Apr; Vol. 95 (4), pp. 892-900. Date of Electronic Publication: 2012 Feb 15.
نوع المنشور: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0376027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-3207 (Electronic) Linking ISSN: 00029165 NLM ISO Abbreviation: Am J Clin Nutr Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [New York, NY] : Elsevier
Original Publication: Bethesda, MD : American Society of Clinical Nutrition
مواضيع طبية MeSH: Aging*, Choline/*administration & dosage , Choline Deficiency/*physiopathology , Diet/*adverse effects , Fatty Liver/*etiology, Adolescent ; Adult ; Aged ; Biopsy ; Child ; Cohort Studies ; Cross-Sectional Studies ; Fatty Liver/pathology ; Female ; Fibrosis ; Humans ; Liver/pathology ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease ; Postmenopause ; Severity of Illness Index ; Surveys and Questionnaires ; Young Adult
مستخلص: Background: There is significant histologic and biochemical overlap between nonalcoholic fatty liver disease (NAFLD) and steatohepatitis associated with choline deficiency.
Objective: We sought to determine whether subjects with biopsy-proven NAFLD and evidence of an inadequate intake of choline had more severe histologic features.
Design: We performed a cross-sectional analysis of 664 subjects enrolled in the multicenter, prospective Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) with baseline data on diet composition (from a recall-based food-frequency questionnaire) within 6 mo of a liver biopsy. Food questionnaires were analyzed with proprietary software to estimate daily intakes of choline. Liver biopsies were centrally read, and consensus was scored with the NASH CRN-developed scoring system. Because choline needs vary by age, sex, and menopausal status, participants were segregated into corresponding categories (children 9-13 y old, males ≥14 y old, premenopausal women ≥19 y old, and postmenopausal women) on the basis of the Institute of Medicine's definition of adequate intake (AI) for choline. Deficient intake was defined as <50% AI.
Results: Postmenopausal women with deficient choline intake had worse fibrosis (P = 0.002) once factors associated with NAFLD (age, race-ethnicity, obesity, elevated triglycerides, diabetes, alcohol use, and steroid use) were considered in multiple ordinal logistic regression models. Choline intake was not identified as a contributor to disease severity in children, men, or premenopausal women.
Conclusion: Decreased choline intake is significantly associated with increased fibrosis in postmenopausal women with NAFLD. The Pioglitazone vs Vitamin E vs Placebo for Treatment of Non-Diabetic Patients With Nonalcoholic Steatohepatitis trial was registered at clinicaltrials.gov as NCT00063622, and the Treatment of Nonalcoholic Fatty Liver Disease in Children trial was registered at clinicaltrials.gov as NCT00063635.
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معلومات مُعتمدة: U01DK061713 United States DK NIDDK NIH HHS; U01 DK061732 United States DK NIDDK NIH HHS; U01DK061731 United States DK NIDDK NIH HHS; U01DK061737 United States DK NIDDK NIH HHS; U01DK061718 United States DK NIDDK NIH HHS; U01DK061732 United States DK NIDDK NIH HHS; U01DK061728 United States DK NIDDK NIH HHS; U01 DK061730 United States DK NIDDK NIH HHS; U01 DK061728 United States DK NIDDK NIH HHS; UL1 TR000454 United States TR NCATS NIH HHS; U01DK061738 United States DK NIDDK NIH HHS; U01DK061734 United States DK NIDDK NIH HHS; U01DK061730 United States DK NIDDK NIH HHS
سلسلة جزيئية: ClinicalTrials.gov NCT00063622; NCT00063635
المشرفين على المادة: N91BDP6H0X (Choline)
تواريخ الأحداث: Date Created: 20120217 Date Completed: 20120507 Latest Revision: 20230318
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3302364
DOI: 10.3945/ajcn.111.020156
PMID: 22338037
قاعدة البيانات: MEDLINE
الوصف
تدمد:1938-3207
DOI:10.3945/ajcn.111.020156