دورية أكاديمية
Prolonged increase in rat hippocampal chemokine signalling after status epilepticus.
العنوان: | Prolonged increase in rat hippocampal chemokine signalling after status epilepticus. |
---|---|
المؤلفون: | Kan AA; Dept. of Neuroscience & Pharmacology, Rudolf Magnus Institute of Neuroscience, The Netherlands., van der Hel WS, Kolk SM, Bos IW, Verlinde SA, van Nieuwenhuizen O, de Graan PN |
المصدر: | Journal of neuroimmunology [J Neuroimmunol] 2012 Apr; Vol. 245 (1-2), pp. 15-22. Date of Electronic Publication: 2012 Feb 20. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8421 (Electronic) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Amsterdam] : Elsevier/North-Holland, c1981- |
مواضيع طبية MeSH: | Chemokine CCL4/*metabolism , Epilepsy, Temporal Lobe/*immunology , Hippocampus/*immunology , Receptors, CCR5/*metabolism , Signal Transduction/*immunology , Status Epilepticus/*immunology, Animals ; Animals, Newborn ; Astrocytes/immunology ; Astrocytes/metabolism ; Disease Models, Animal ; Epilepsy, Temporal Lobe/metabolism ; Hippocampus/metabolism ; Male ; Rats ; Rats, Wistar ; Reaction Time/immunology ; Status Epilepticus/metabolism ; Up-Regulation/immunology |
مستخلص: | Temporal lobe epilepsy (TLE) is one of the most common focal epilepsy syndromes. In a genome-wide expression study of the human TLE hippocampus we previously showed up-regulation of genes involved in chemokine signalling. Here we investigate in the rat pilocarpine model for TLE, whether changes in chemokine signalling occur during epileptogenesis and are persistent. Therefore we analysed hippocampal protein expression and cellular localisation of CCL2, CCL4, CCR1 and CCR5 after status epilepticus. We found increased CCL4 (but not CCL2) expression in specific populations of hilar astrocytes at 2 and 19 weeks after SE concomitant with a persistent up-regulation of its receptor CCR5. Our results show an early and persistent up-regulation of CCL4/CCR5 signalling during epileptogenesis and suggest that CCL4 signalling, rather than CCL2 signalling, could have a role in the epileptogenic process. (Copyright © 2012 Elsevier B.V. All rights reserved.) |
المشرفين على المادة: | 0 (Chemokine CCL4) 0 (Receptors, CCR5) |
تواريخ الأحداث: | Date Created: 20120223 Date Completed: 20120605 Latest Revision: 20120417 |
رمز التحديث: | 20221213 |
DOI: | 10.1016/j.jneuroim.2012.01.012 |
PMID: | 22353418 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1872-8421 |
---|---|
DOI: | 10.1016/j.jneuroim.2012.01.012 |