دورية أكاديمية
What should we know about metabolic syndrome and lipodystrophy in AIDS?
| العنوان: | What should we know about metabolic syndrome and lipodystrophy in AIDS? |
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| المؤلفون: | Signorini DJ; Escola Nacional de Saúde Pública, Fiocruz, Brazil. dariohart@terra.com.br, Monteiro MC, Andrade Mde F, Signorini DH, Eyer-Silva Wde A |
| المصدر: | Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2012 Jan-Feb; Vol. 58 (1), pp. 70-5. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Associação Médica Brasileira Country of Publication: Brazil NLM ID: 9308586 Publication Model: Print Cited Medium: Internet ISSN: 1806-9282 (Electronic) Linking ISSN: 01044230 NLM ISO Abbreviation: Rev Assoc Med Bras (1992) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: São Paulo : Associação Médica Brasileira |
| مواضيع طبية MeSH: | HIV Infections/*complications , HIV-Associated Lipodystrophy Syndrome/*epidemiology , Lipodystrophy/*epidemiology , Metabolic Syndrome/*epidemiology, Adolescent ; Adult ; Aged ; Anti-HIV Agents/adverse effects ; Antiretroviral Therapy, Highly Active/adverse effects ; Cross-Sectional Studies ; Female ; HIV Infections/drug therapy ; HIV-Associated Lipodystrophy Syndrome/chemically induced ; Humans ; Lipodystrophy/chemically induced ; Male ; Metabolic Syndrome/complications ; Middle Aged ; Prevalence ; Risk Factors ; Young Adult |
| مستخلص: | Objective: Prevalence of chronic complications of HIV infection is increasing and early recognition and treatment of the components of metabolic syndrome (MS) are essential to prevent cardiovascular and metabolic complications. Considering this, we performed a cross-sectional study on the prevalence and risk-factors for MS among HIV-infected subjects. Methods: A total of 819 patients followed at a large outpatient HIV unit were assessed by an interviewer-administered questionnaire that recorded several demographic, epidemiologic, clinical, laboratory, and social variables. Lipodystrophy diagnosis relied on agreement between patient's self-report and physician's observation of altered body-fat deposits. The presence of three or more of the following characteristics identified MS: increased waist circumference, hypertriglyceridemia, low HDL cholesterol level, hypertension, and hyperglycemia. We used logistic regression analyses to study variables independently associated with MS. Results: The prevalence of MS was 20.6% and that of lipodystrophy was 38.5%. 61 (36.1%) out of 169 patients with MS had also lipodystrophy. Patients with metabolic syndrome were significantly more likely to be older (OR = 1.08), had higher CD4 counts (OR = 1.001), had an increased body mass index (OR = 1.27) and had longer exposure to antiretroviral therapy (OR = 1.01) than those without metabolic syndrome. Conclusion: Both traditional risk factors for cardiovascular disease and factors associated with HIV infection itself, such as an increased CD4 cell count and a longer exposure to antiretroviral therapy, seem to be associated with metabolic syndrome in the present study population. |
| المشرفين على المادة: | 0 (Anti-HIV Agents) |
| تواريخ الأحداث: | Date Created: 20120307 Date Completed: 20120713 Latest Revision: 20171116 |
| رمز التحديث: | 20240628 |
| PMID: | 22392319 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1806-9282 |
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