دورية أكاديمية
The risk factors to predict acute rejection in liver transplantation.
| العنوان: | The risk factors to predict acute rejection in liver transplantation. |
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| المؤلفون: | Wang YC; Chang-Gung Transplantation Institute, Department of Liver and Transplantation Surgery, Chang-Gung Memorial Hospital, Chang-Gung University Medical School, Taoyuan, Taiwan., Wu TJ, Wu TH, Lee CF, Chou HS, Chan KM, Lee WC |
| المصدر: | Transplantation proceedings [Transplant Proc] 2012 Mar; Vol. 44 (2), pp. 526-8. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Inc Country of Publication: United States NLM ID: 0243532 Publication Model: Print Cited Medium: Internet ISSN: 1873-2623 (Electronic) Linking ISSN: 00411345 NLM ISO Abbreviation: Transplant Proc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, N.Y. : Elsevier Science Inc. Original Publication: New York Stratton. |
| مواضيع طبية MeSH: | Graft Rejection/*etiology , Liver Transplantation/*adverse effects, Acute Disease ; Adult ; Age Factors ; Alanine Transaminase/blood ; Biomarkers/blood ; CD8-Positive T-Lymphocytes/immunology ; Chi-Square Distribution ; Creatinine/blood ; Female ; Graft Rejection/blood ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Humans ; Immunosuppressive Agents/therapeutic use ; Liver Transplantation/immunology ; Logistic Models ; Lymphocyte Count ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Proportional Hazards Models ; ROC Curve ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Taiwan ; Time Factors ; Treatment Outcome |
| مستخلص: | Purpose: The aim of this study was to evaluate risk factors for an acute cellular rejection episode (ARE) among adult liver transplant (OLT) patients. Materials and Methods: We retrospectively reviewed 110 consecutive patients who underwent OLT between May 2007 and December 2010. The diagnosis of ARE was based upon clinical and biochemical data; liver biopsy was only performed when clinical presentation was equivocal. We recorded donor and recipient characteristics, perioperative immune status, and postoperative laboratory data. Forty patients (36.4%) who suffered a clinical rejection episode and received pulsed or recycled steroid therapy (R group), were compared with 70 (63.6%) free of rejection (N group). Results: The mean age of R recipients was 46.61±9.97 years, which was younger than the N group (51.86±8.37, P=.005). R group patients displayed a lower pre-OLT creatinine (P=.016) and higher alanine aminotransferase (P=.048). Cox regression model showed recipient age to be the only significant factor to predict ARE (odds ratio=1.071, P=.003). The cutpoint of age was 46 years by receiver operating characteristic analysis. Patients younger than 46 years showed higher initial CD8+ T-cell counts (P=.038). Conclusion: Recipient age was significantly associated with ARE; younger patients showed higher CD8+ lymphocyte counts than older patients. More aggressive immunosuppression should be considered for younger recipients to prevent ARE. (Copyright © 2012 Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Immunosuppressive Agents) AYI8EX34EU (Creatinine) EC 2.6.1.2 (Alanine Transaminase) |
| تواريخ الأحداث: | Date Created: 20120314 Date Completed: 20120801 Latest Revision: 20220316 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.transproceed.2012.01.041 |
| PMID: | 22410062 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-2623 |
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| DOI: | 10.1016/j.transproceed.2012.01.041 |