دورية أكاديمية
أعرض في EDS

Analysis of subtelomeric virulence gene families in Plasmodium falciparum by comparative transcriptional profiling.

التفاصيل البيبلوغرافية
العنوان: Analysis of subtelomeric virulence gene families in Plasmodium falciparum by comparative transcriptional profiling.
المؤلفون: Witmer K; Swiss Tropical and Public Health Institute, 4051 Basel, Switzerland., Schmid CD, Brancucci NM, Luah YH, Preiser PR, Bozdech Z, Voss TS
المصدر: Molecular microbiology [Mol Microbiol] 2012 Apr; Vol. 84 (2), pp. 243-59. Date of Electronic Publication: 2012 Mar 22.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8712028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2958 (Electronic) Linking ISSN: 0950382X NLM ISO Abbreviation: Mol Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, OX ; Boston, MA : Blackwell Scientific Publications, c1987-
مواضيع طبية MeSH: Gene Expression Regulation* , Genes, Protozoan*, Plasmodium falciparum/*genetics , Plasmodium falciparum/*pathogenicity , Virulence Factors/*biosynthesis , Virulence Factors/*genetics, Gene Expression Profiling ; Promoter Regions, Genetic ; Transcription, Genetic
مستخلص: The Plasmodium falciparum genome is equipped with several subtelomeric gene families that are implicated in parasite virulence and immune evasion. Members of these families are uniformly positioned within heterochromatic domains and are thus subject to variegated expression. The best-studied example is that of the var family encoding the major parasite virulence factor P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 undergoes antigenic variation through switches in mutually exclusive var gene transcription. var promoters function as crucial regulatory elements in the underlying epigenetic control strategy. Here, we analysed promoters of upsA, upsB and upsC var, rifA1-type rif, stevor, phist and pfmc-2tm genes and investigated their role in endogenous gene transcription by comparative genome-wide expression profiling of transgenic parasite lines. We find that the three major var promoter types are functionally equal and play an essential role in singular gene choice. Unlike var promoters, promoters of non-var families are not silenced by default, and transcription of non-var families is not subject to the same mode of mutually exclusive transcription as has been observed for var genes. Our findings identified a differential logic in the regulation of var and other subtelomeric virulence gene families, which will have important implications for our understanding and future analyses of phenotypic variation in malaria parasites.
(© 2012 Blackwell Publishing Ltd.)
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سلسلة جزيئية: GEO GSE31829
المشرفين على المادة: 0 (Virulence Factors)
تواريخ الأحداث: Date Created: 20120323 Date Completed: 20120727 Latest Revision: 20211021
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3491689
DOI: 10.1111/j.1365-2958.2012.08019.x
PMID: 22435676
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2958
DOI:10.1111/j.1365-2958.2012.08019.x