دورية أكاديمية
Analysis of subtelomeric virulence gene families in Plasmodium falciparum by comparative transcriptional profiling.
العنوان: | Analysis of subtelomeric virulence gene families in Plasmodium falciparum by comparative transcriptional profiling. |
---|---|
المؤلفون: | Witmer K; Swiss Tropical and Public Health Institute, 4051 Basel, Switzerland., Schmid CD, Brancucci NM, Luah YH, Preiser PR, Bozdech Z, Voss TS |
المصدر: | Molecular microbiology [Mol Microbiol] 2012 Apr; Vol. 84 (2), pp. 243-59. Date of Electronic Publication: 2012 Mar 22. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8712028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2958 (Electronic) Linking ISSN: 0950382X NLM ISO Abbreviation: Mol Microbiol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Oxford, OX ; Boston, MA : Blackwell Scientific Publications, c1987- |
مواضيع طبية MeSH: | Gene Expression Regulation* , Genes, Protozoan*, Plasmodium falciparum/*genetics , Plasmodium falciparum/*pathogenicity , Virulence Factors/*biosynthesis , Virulence Factors/*genetics, Gene Expression Profiling ; Promoter Regions, Genetic ; Transcription, Genetic |
مستخلص: | The Plasmodium falciparum genome is equipped with several subtelomeric gene families that are implicated in parasite virulence and immune evasion. Members of these families are uniformly positioned within heterochromatic domains and are thus subject to variegated expression. The best-studied example is that of the var family encoding the major parasite virulence factor P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 undergoes antigenic variation through switches in mutually exclusive var gene transcription. var promoters function as crucial regulatory elements in the underlying epigenetic control strategy. Here, we analysed promoters of upsA, upsB and upsC var, rifA1-type rif, stevor, phist and pfmc-2tm genes and investigated their role in endogenous gene transcription by comparative genome-wide expression profiling of transgenic parasite lines. We find that the three major var promoter types are functionally equal and play an essential role in singular gene choice. Unlike var promoters, promoters of non-var families are not silenced by default, and transcription of non-var families is not subject to the same mode of mutually exclusive transcription as has been observed for var genes. Our findings identified a differential logic in the regulation of var and other subtelomeric virulence gene families, which will have important implications for our understanding and future analyses of phenotypic variation in malaria parasites. (© 2012 Blackwell Publishing Ltd.) |
References: | Nature. 1998 Apr 23;392(6678):828-31. (PMID: 9572143) J Infect Dis. 2005 Sep 15;192(6):1119-26. (PMID: 16107968) Eukaryot Cell. 2006 Aug;5(8):1206-14. (PMID: 16896206) PLoS Pathog. 2009 Oct;5(10):e1000644. (PMID: 19898609) Cell. 1995 Jul 14;82(1):77-87. (PMID: 7541722) Am J Trop Med Hyg. 1991 Feb;44(2):168-75. (PMID: 2012260) J Mol Biol. 2008 Oct 3;382(2):288-97. (PMID: 18656490) Nature. 2006 Feb 23;439(7079):1004-8. (PMID: 16382237) Mol Biochem Parasitol. 2000 Mar 15;107(1):103-15. (PMID: 10717306) J Exp Med. 1984 Jun 1;159(6):1567-75. (PMID: 6374009) Nucleic Acids Res. 2006;34(22):6696-707. (PMID: 17148488) Mol Microbiol. 2007 Jun;64(6):1486-98. (PMID: 17555435) Cell. 2008 Jul 11;134(1):48-61. (PMID: 18614010) Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9171-4. (PMID: 1924380) EMBO Rep. 2007 Oct;8(10):959-65. (PMID: 17762879) BMC Bioinformatics. 2007 Sep 19;8:350. (PMID: 17880708) Mol Biochem Parasitol. 2007 Nov;156(1):51-61. (PMID: 17719658) Genome Biol. 2009;10(10):R117. (PMID: 19849836) J Infect Dis. 2007 Mar 1;195(5):748-55. (PMID: 17262719) Cell. 1995 Jul 14;82(1):101-10. (PMID: 7606775) Cell. 2005 Apr 8;121(1):25-36. (PMID: 15820676) Mol Med. 2002 Jan;8(1):16-23. (PMID: 11984002) Nature. 2000 Oct 26;407(6807):1018-22. (PMID: 11069183) Infect Immun. 2007 Jul;75(7):3621-32. (PMID: 17470539) PLoS Pathog. 2010 Feb 26;6(2):e1000784. (PMID: 20195509) Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9333-8. (PMID: 10430943) Cell. 1990 Nov 16;63(4):751-62. (PMID: 2225075) Mol Biochem Parasitol. 2009 Dec;168(2):186-90. (PMID: 19682502) EMBO J. 1998 Sep 15;17(18):5418-26. (PMID: 9736619) Malar J. 2007 Jun 12;6:78. (PMID: 17565661) Nature. 2001 Aug 30;412(6850):875-6. (PMID: 11528468) Mol Biochem Parasitol. 2006 Dec;150(2):211-8. (PMID: 16996149) Infect Immun. 2003 Nov;71(11):6229-33. (PMID: 14573641) Int J Parasitol. 2010 Jan;40(1):35-43. (PMID: 19666023) Genome Biol. 2006;7(2):R12. (PMID: 16507167) Mol Biochem Parasitol. 2000 Oct;110(2):391-7. (PMID: 11071291) Eukaryot Cell. 2005 Feb;4(2):490-2. (PMID: 15701812) PLoS Biol. 2009 Apr 14;7(4):e84. (PMID: 19402747) Bioinformatics. 2004 Nov 22;20(17):3246-8. (PMID: 15180930) Genome Res. 2004 Jun;14(6):1052-9. (PMID: 15140830) J Biol Chem. 2006 Apr 14;281(15):9942-52. (PMID: 16455655) Infect Immun. 2008 Jul;76(7):3329-36. (PMID: 18474651) PLoS One. 2008 Apr 23;3(4):e1982. (PMID: 18431472) Nature. 1992 Jun 25;357(6380):689-92. (PMID: 1614515) Am J Pathol. 1985 Jun;119(3):385-401. (PMID: 3893148) Mol Microbiol. 2003 Dec;50(5):1527-38. (PMID: 14651636) Infect Immun. 2006 Jul;74(7):3904-11. (PMID: 16790763) Nature. 2002 Oct 3;419(6906):498-511. (PMID: 12368864) Infect Immun. 2002 Dec;70(12):7013-21. (PMID: 12438381) Malar J. 2008 Jul 23;7:137. (PMID: 18651957) Mol Biochem Parasitol. 2000 Feb 5;105(2):311-5. (PMID: 10693754) Parasitology. 2008 Feb;135(2):155-67. (PMID: 17931459) J Exp Med. 2004 May 3;199(9):1179-90. (PMID: 15123742) BMC Genomics. 2011 Feb 18;12:119. (PMID: 21332983) Mol Microbiol. 2009 Sep;73(6):1171-85. (PMID: 19708920) Lancet. 1990 Dec 15;336(8729):1457-60. (PMID: 1979090) J Biol Chem. 2003 Sep 5;278(36):34125-32. (PMID: 12832422) J Parasitol. 1979 Jun;65(3):418-20. (PMID: 383936) J Biochem. 1965 May;57(5):667-77. (PMID: 4953866) PLoS Pathog. 2010 Sep 02;6(9):e1001083. (PMID: 20824088) Mol Microbiol. 2003 Jun;48(6):1593-607. (PMID: 12791141) Int J Parasitol. 2009 Nov;39(13):1425-39. (PMID: 19463825) Mol Microbiol. 2007 Dec;66(6):1296-305. (PMID: 18028313) Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14863-8. (PMID: 9843981) J Cell Biol. 2005 Nov 21;171(4):587-92. (PMID: 16301328) Mol Biochem Parasitol. 1998 Nov 30;97(1-2):161-76. (PMID: 9879895) J Exp Med. 1999 Nov 15;190(10):1393-404. (PMID: 10562315) PLoS Biol. 2003 Oct;1(1):E5. (PMID: 12929205) Annu Rev Microbiol. 2001;55:673-707. (PMID: 11544371) Mol Microbiol. 2007 Oct;66(1):139-50. (PMID: 17725559) Malar J. 2003 Sep 10;2:27. (PMID: 14565852) Mol Microbiol. 2007 Jun;64(6):1621-34. (PMID: 17555442) PLoS One. 2008;3(11):e3779. (PMID: 19020666) Cell. 1984 Nov;39(1):203-11. (PMID: 6091912) Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):899-902. (PMID: 17209011) BMC Genomics. 2008 Jan 15;9:19. (PMID: 18197962) Genes Dev. 2003 Sep 15;17(18):2245-58. (PMID: 12952896) PLoS Pathog. 2009 Jan;5(1):e1000256. (PMID: 19119419) Mol Biochem Parasitol. 1988 Jun;29(2-3):117-24. (PMID: 2842673) PLoS Pathog. 2006 Mar;2(3):e22. (PMID: 16518466) Cell Host Microbe. 2009 Feb 19;5(2):179-90. (PMID: 19218088) Int J Parasitol. 2009 May;39(6):655-64. (PMID: 19162031) Cell. 2005 Apr 8;121(1):13-24. (PMID: 15820675) Genetics. 2005 Aug;170(4):1589-600. (PMID: 15965256) Nat Rev Microbiol. 2009 Jul;7(7):493-503. (PMID: 19503065) Cell Host Microbe. 2007 Aug 16;2(2):130-8. (PMID: 18005727) PLoS Pathog. 2009 Feb;5(2):e1000307. (PMID: 19229319) Eukaryot Cell. 2002 Dec;1(6):926-35. (PMID: 12477793) Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5414-9. (PMID: 15797990) Infect Immun. 1995 Jun;63(6):2323-6. (PMID: 7768616) Cell. 1995 Jul 14;82(1):89-100. (PMID: 7606788) Nucleic Acids Res. 2006 Feb 21;34(4):1166-73. (PMID: 16493140) PLoS Pathog. 2009 Sep;5(9):e1000569. (PMID: 19730695) Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9655-60. (PMID: 19497874) Int J Parasitol. 2003 Jan;33(1):29-45. (PMID: 12547344) Nature. 1978 Jun 22;273(5664):621-2. (PMID: 351412) |
سلسلة جزيئية: | GEO GSE31829 |
المشرفين على المادة: | 0 (Virulence Factors) |
تواريخ الأحداث: | Date Created: 20120323 Date Completed: 20120727 Latest Revision: 20211021 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC3491689 |
DOI: | 10.1111/j.1365-2958.2012.08019.x |
PMID: | 22435676 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1365-2958 |
---|---|
DOI: | 10.1111/j.1365-2958.2012.08019.x |