دورية أكاديمية
Photostability and skin penetration of different E-resveratrol-loaded supramolecular structures.
| العنوان: | Photostability and skin penetration of different E-resveratrol-loaded supramolecular structures. |
|---|---|
| المؤلفون: | Detoni CB; Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Souto GD, da Silva AL, Pohlmann AR, Guterres SS |
| المصدر: | Photochemistry and photobiology [Photochem Photobiol] 2012 Jul-Aug; Vol. 88 (4), pp. 913-21. Date of Electronic Publication: 2012 Apr 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Photobiology Country of Publication: United States NLM ID: 0376425 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1751-1097 (Electronic) Linking ISSN: 00318655 NLM ISO Abbreviation: Photochem Photobiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2004->: Lawrence KS : American Society for Photobiology Original Publication: Augusta, GA: American Society for Photobiology, <1996-> |
| مواضيع طبية MeSH: | Dermis/*metabolism , Epidermis/*metabolism , Liposomes/*chemistry , Nanocapsules/*chemistry , Nanoparticles/*chemistry , Stilbenes/*metabolism , Stilbenes/*radiation effects, Administration, Cutaneous ; Animals ; Cell Membrane Permeability ; Chromatography, High Pressure Liquid ; Diffusion Chambers, Culture ; Drug Stability ; Ethanol ; Kinetics ; Liposomes/radiation effects ; Liposomes/ultrastructure ; Microscopy, Electron, Transmission ; Nanocapsules/radiation effects ; Nanocapsules/ultrastructure ; Nanoparticles/radiation effects ; Nanoparticles/ultrastructure ; Particle Size ; Photolysis ; Resveratrol ; Stilbenes/chemistry ; Swine ; Ultraviolet Rays |
| مستخلص: | It is desirable and challenging to prevent E-resveratrol (E-RSV) from photoisomerizing to its Z-configuration to preserve its biological and pharmacological activities. The aim of this research was to evaluate the photostability of E-RSV-loaded supramolecular structures and the skin penetration profile of chemically and physically stable nanoestructured formulations. Different supramolecular structures were developed to act as carriers for E-RSV, that is, liposomes, polymeric lipid-core nanocapsules and nanospheres and solid lipid nanoparticles. The degrees of photostability of these formulations were compared with that of an ethanolic solution of E-RSV. The skin penetration profiles of the stable formulations were obtained using vertical diffusion cells (protected from light and under UVA radiation) with porcine skin as the membrane, followed by tape stripping and separation of the viable epidermis and dermis in a heated water bath. Photoisomerization was significantly delayed by the association of resveratrol with the nanocarriers independently of the supramolecular structure. Liposomes were the particles capable of maintaining E-RSV concentration for the longest time. On the other hand, E-RSV-loaded liposomes reduced in size showing low physical stability under UVA radiation. In the dark, the skin penetration profiles were very similar, but under UVA radiation the E-RSV-loaded nanocarriers showed increasing amounts in the total epidermis. (© 2012 Wiley Periodicals, Inc. Photochemistry and Photobiology © 2012 The American Society of Photobiology.) |
| المشرفين على المادة: | 0 (Liposomes) 0 (Nanocapsules) 0 (Stilbenes) 3K9958V90M (Ethanol) Q369O8926L (Resveratrol) |
| تواريخ الأحداث: | Date Created: 20120327 Date Completed: 20130117 Latest Revision: 20181201 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/j.1751-1097.2012.01147.x |
| PMID: | 22443373 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1751-1097 |
|---|---|
| DOI: | 10.1111/j.1751-1097.2012.01147.x |