دورية أكاديمية
All-optical phase modulation for integrated interferometric biosensors.
| العنوان: | All-optical phase modulation for integrated interferometric biosensors. |
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| المؤلفون: | Dante S; Research Center on Nanoscience and Nanotechnology CIN2 (CSIC) and CIBER-BBN, Campus UAB, 08193 Bellaterra, Barcelona, Spain., Duval D, Sepúlveda B, González-Guerrero AB, Sendra JR, Lechuga LM |
| المصدر: | Optics express [Opt Express] 2012 Mar 26; Vol. 20 (7), pp. 7195-205. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Optica Publishing Group Country of Publication: United States NLM ID: 101137103 Publication Model: Print Cited Medium: Internet ISSN: 1094-4087 (Electronic) Linking ISSN: 10944087 NLM ISO Abbreviation: Opt Express Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : Optica Publishing Group Original Publication: Washington, DC : Optical Society of America, 1997- |
| مواضيع طبية MeSH: | Biosensing Techniques/*instrumentation , Immunoassay/*instrumentation , Interferometry/*instrumentation, Equipment Design ; Equipment Failure Analysis ; Systems Integration |
| مستخلص: | We present the theoretical and the experimental implementation of an all-optical phase modulation system in integrated Mach-Zehnder Interferometers to solve the drawbacks related to the periodic nature of the interferometric signal. Sensor phase is tuned by modulating the emission wavelength of low-cost commercial laser diodes by changing their output power. FFT deconvolution of the signal allows for direct phase readout, immune to sensitivity variations and to light intensity fluctuations. This simple phase modulation scheme increases the signal-to-noise ratio of the measurements in one order of magnitude, rendering in a sensor with a detection limit of 1.9·10⁻⁷ RIU. The viability of the all-optical modulation approach is demonstrated with an immunoassay detection as a biosensing proof of concept. |
| تواريخ الأحداث: | Date Created: 20120329 Date Completed: 20120801 Latest Revision: 20181023 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1364/OE.20.007195 |
| PMID: | 22453401 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1094-4087 |
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| DOI: | 10.1364/OE.20.007195 |