دورية أكاديمية
Cutting edge: Asymmetric memory T cell division in response to rechallenge.
| العنوان: | Cutting edge: Asymmetric memory T cell division in response to rechallenge. |
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| المؤلفون: | Ciocca ML; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA., Barnett BE, Burkhardt JK, Chang JT, Reiner SL |
| المصدر: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2012 May 01; Vol. 188 (9), pp. 4145-8. Date of Electronic Publication: 2012 Mar 30. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Bethesda, MD : American Association of Immunologists Original Publication: Baltimore : Williams & Wilkins, c1950- |
| مواضيع طبية MeSH: | Immunologic Memory*, CD8-Positive T-Lymphocytes/*immunology , Cell Division/*immunology , Lymphocytic Choriomeningitis/*immunology , Lymphocytic choriomeningitis virus/*immunology , Signal Transduction/*immunology, Animals ; Cell Division/genetics ; Lymphocytic Choriomeningitis/genetics ; Mice ; Mice, Transgenic ; Signal Transduction/genetics ; Transcription, Genetic/genetics ; Transcription, Genetic/immunology |
| مستخلص: | Clonal selection of a T cell for use in the immune response appears to necessitate proliferative expansion and terminal effector differentiation of some cellular progeny, while reserving other progeny as less-differentiated memory cells. It has been suggested that asymmetric cell division may promote initial cell diversification. Stem cell-like models of adaptive immunity might predict that subsequent encounters with a pathogen would evoke reiterative, self-renewing, asymmetric division by memory T cells. In this study, we show that murine memory CD8(+) T cells can divide asymmetrically in response to secondary encounter with pathogen. Critical regulators of signaling and transcription are partitioned to one side of the mitotic spindle in rechallenged memory T cells, and two phenotypically distinct populations of daughter cells are evident from the earliest divisions. Memory T cells may thus use asymmetric cell division to generate cellular heterogeneity when faced with pathogen rechallenge. |
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| معلومات مُعتمدة: | DP2 OD008469-01 United States OD NIH HHS; R56 AI076458 United States AI NIAID NIH HHS; DP2OD008469 United States OD NIH HHS; T32HD007516 United States HD NICHD NIH HHS; DK080949 United States DK NIDDK NIH HHS; T32GM07229 United States GM NIGMS NIH HHS; K08 DK080949-05 United States DK NIDDK NIH HHS; R01 AI061699-07 United States AI NIAID NIH HHS; DP2 OD008469 United States OD NIH HHS; AI061699 United States AI NIAID NIH HHS; T32 HD007516 United States HD NICHD NIH HHS; K08 DK080949 United States DK NIDDK NIH HHS; United States HHMI Howard Hughes Medical Institute; 3T32GM007170-36S1 United States GM NIGMS NIH HHS; T32 GM007229 United States GM NIGMS NIH HHS; T32 GM007170 United States GM NIGMS NIH HHS; K08 DK080949-06 United States DK NIDDK NIH HHS; R01 AI076458-05 United States AI NIAID NIH HHS; AI076458 United States AI NIAID NIH HHS; R01 AI042370-15 United States AI NIAID NIH HHS; R01 AI065644-05 United States AI NIAID NIH HHS; R01 AI061699-08 United States AI NIAID NIH HHS; R01 AI065644 United States AI NIAID NIH HHS; R01 AI042370 United States AI NIAID NIH HHS; AI065644 United States AI NIAID NIH HHS; R01 AI061699 United States AI NIAID NIH HHS; AI042370 United States AI NIAID NIH HHS; R01 AI076458 United States AI NIAID NIH HHS; R01 AI065644-04 United States AI NIAID NIH HHS |
| تواريخ الأحداث: | Date Created: 20120403 Date Completed: 20120611 Latest Revision: 20220223 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC3331961 |
| DOI: | 10.4049/jimmunol.1200176 |
| PMID: | 22467651 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1550-6606 |
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| DOI: | 10.4049/jimmunol.1200176 |