دورية أكاديمية
أعرض في EDS

Crystal structure of an HIV-binding recombinant fragment of human CD4.

التفاصيل البيبلوغرافية
العنوان: Crystal structure of an HIV-binding recombinant fragment of human CD4.
المؤلفون: Ryu SE; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032., Kwong PD, Truneh A, Porter TG, Arthos J, Rosenberg M, Dai XP, Xuong NH, Axel R, Sweet RW, et. al.
المصدر: Nature [Nature] 1990 Nov 29; Vol. 348 (6300), pp. 419-26.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium: Print ISSN: 0028-0836 (Print) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
أسماء مطبوعة: Publication: Basingstoke : Nature Publishing Group
Original Publication: London, Macmillan Journals ltd.
مواضيع طبية MeSH: CD4 Antigens/*ultrastructure , HIV Envelope Protein gp120/*metabolism, Amino Acid Sequence ; Antibodies, Monoclonal/immunology ; Binding Sites ; Biological Evolution ; Computer Graphics ; Crystallography ; DNA Mutational Analysis ; HLA-D Antigens/metabolism ; Membrane Fusion ; Models, Molecular ; Molecular Sequence Data ; Molecular Structure ; Peptide Fragments ; Protein Conformation ; Recombinant Proteins ; Structure-Activity Relationship ; X-Ray Diffraction
مستخلص: CD4 glycoprotein on the surface of T cells helps in the immune response and is the receptor for HIV infection. The structure of a soluble fragment of CD4 determined at 2.3 A resolution reveals that the molecule has two intimately associated immunoglobulin-like domains. Residues implicated in HIV recognition by analysis of mutants and antibody binding are salient features in domain D1. Domain D2 is distinguished by a variation on the beta-strand topologies of antibody domains and by an intra-sheet disulphide bridge.
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معلومات مُعتمدة: R01 GM034102 United States GM NIGMS NIH HHS
المشرفين على المادة: 0 (Antibodies, Monoclonal)
0 (CD4 Antigens)
0 (HIV Envelope Protein gp120)
0 (HLA-D Antigens)
0 (Peptide Fragments)
0 (Recombinant Proteins)
تواريخ الأحداث: Date Created: 19901129 Date Completed: 19910107 Latest Revision: 20240604
رمز التحديث: 20240604
مُعرف محوري في PubMed: PMC5638305
DOI: 10.1038/348419a0
PMID: 2247146
قاعدة البيانات: MEDLINE
الوصف
تدمد:0028-0836
DOI:10.1038/348419a0