دورية أكاديمية
أعرض في EDS

The role of miRNAs in human papilloma virus (HPV)-associated cancers: bridging between HPV-related head and neck cancer and cervical cancer.

التفاصيل البيبلوغرافية
العنوان: The role of miRNAs in human papilloma virus (HPV)-associated cancers: bridging between HPV-related head and neck cancer and cervical cancer.
المؤلفون: Lajer CB; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Denmark. christel.lajer@rh.regionh.dk, Garnæs E, Friis-Hansen L, Norrild B, Therkildsen MH, Glud M, Rossing M, Lajer H, Svane D, Skotte L, Specht L, Buchwald C, Nielsen FC
المصدر: British journal of cancer [Br J Cancer] 2012 Apr 24; Vol. 106 (9), pp. 1526-34.
نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
أسماء مطبوعة: Publication: 2002- : London : Nature Publishing Group on behalf of Cancer Research UK
Original Publication: London, Lewis.
مواضيع طبية MeSH: Biomarkers, Tumor/*genetics , Carcinoma, Squamous Cell/*genetics , Head and Neck Neoplasms/*genetics , MicroRNAs/*genetics , Papillomaviridae/*genetics , Papillomavirus Infections/*genetics, Adolescent ; Biomarkers, Tumor/metabolism ; Carcinoma, Squamous Cell/virology ; Case-Control Studies ; Child ; DNA, Viral/genetics ; Female ; Gene Expression Profiling ; Head and Neck Neoplasms/virology ; Humans ; Laser Capture Microdissection ; Male ; Middle Aged ; Neoplasm Staging ; Oligonucleotide Array Sequence Analysis ; Papillomavirus Infections/virology ; Prognosis ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction
مستخلص: Background: Although the role of human papilloma virus (HPV) in cervical squamous cell carcinoma (CSCC) is well established, the role in head and neck SCC (HNSCC) is less clear. MicroRNAs (miRNAs) have a role in the cancer development, and HPV status may affect the miRNA expression pattern in HNSCC. To explore the influence of HPV in HNSCC, we made a comparative miRNA profile of HPV-positive (HPV+) and HPV-negative (HPV-) HNSCC against CSCC.
Methods: Fresh frozen and laser microdissected-paraffin-embedded samples obtained from patients with HPV+/HPV- HNSCC, CSCC and controls were used for microarray analysis. Differentially expressed miRNAs in the HPV+ and HPV- HNSCC samples were compared with the differentially expressed miRNAs in the CSCC samples.
Results: Human papilloma virus positive (+) HNSCC had a distinct miRNA profile compared with HPV- HNSCC. Significantly more similarity was seen between HPV+ HNSCC and CSCC than HPV- and CSCC. A set of HPV core miRNAs were identified. Of these especially the miR-15a/miR-16/miR195/miR-497 family, miR-143/miR-145 and the miR-106-363 cluster appear to be important within the known HPV pathogenesis.
Conclusion: This study adds new knowledge to the known pathogenic pathways of HPV and substantiates the oncogenic role of HPV in subsets of HNSCCs.
التعليقات: Erratum in: Br J Cancer. 2017 Jul 13;:. (PMID: 28704839)
References: Cancer Res. 2009 Jul 1;69(13):5553-9. (PMID: 19549910)
Cancer Res. 2007 Jun 15;67(12):5699-707. (PMID: 17575136)
Int J Cancer. 2008 Jun 15;122(12):2656-64. (PMID: 18360824)
Mol Cancer Res. 2003 Oct;1(12):882-91. (PMID: 14573789)
Cancer Res. 2007 May 15;67(10):4605-19. (PMID: 17510386)
PLoS One. 2010 Jul 26;5(7):e11780. (PMID: 20668671)
Nat Biotechnol. 2008 Apr;26(4):462-9. (PMID: 18362881)
Cancer Sci. 2007 Dec;98(12):1914-20. (PMID: 17892514)
Head Neck. 2011 Apr;33(4):504-12. (PMID: 20652977)
J Pathol. 1999 Sep;189(1):12-9. (PMID: 10451482)
PLoS One. 2010 May 12;5(5):e10615. (PMID: 20485546)
Int J Cancer. 2009 Jul 15;125(2):362-6. (PMID: 19330833)
Oral Oncol. 2009 Apr-May;45(4-5):309-16. (PMID: 18804401)
Mod Pathol. 2010 Jun;23(6):814-23. (PMID: 20348879)
Front Biosci. 2008 Jan 01;13:1003-17. (PMID: 17981607)
DNA Cell Biol. 2007 May;26(5):311-20. (PMID: 17504027)
Br J Cancer. 2011 Mar 1;104(5):830-40. (PMID: 21326242)
Virus Genes. 2010 Feb;40(1):1-13. (PMID: 19838783)
Biochim Biophys Acta. 2011 Nov-Dec;1809(11-12):668-77. (PMID: 21616186)
PLoS One. 2008 Jul 02;3(7):e2557. (PMID: 18596939)
J Eur Acad Dermatol Venereol. 2009 Oct;23(10):1147-55. (PMID: 19453788)
APMIS. 2010 Jun;118(6-7):510-9. (PMID: 20553531)
Genome Med. 2010 Feb 01;2(2):9. (PMID: 20353613)
APMIS. 2010 Jun;118(6-7):471-93. (PMID: 20553529)
J Clin Oncol. 2009 Apr 20;27(12):1992-8. (PMID: 19289615)
Cancer Biol Ther. 2010 Dec 15;10(12):1224-32. (PMID: 21139417)
Int J Oral Surg. 1983 Dec;12(6):418-24. (PMID: 6325356)
Proc Finn Dent Soc. 1983;79(1):1-8. (PMID: 6306646)
المشرفين على المادة: 0 (Biomarkers, Tumor)
0 (DNA, Viral)
0 (MicroRNAs)
0 (RNA, Messenger)
تواريخ الأحداث: Date Created: 20120405 Date Completed: 20120619 Latest Revision: 20220331
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3341860
DOI: 10.1038/bjc.2012.109
PMID: 22472886
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-1827
DOI:10.1038/bjc.2012.109