دورية أكاديمية
أعرض في EDS

Distinct contribution of human cord blood-derived endothelial colony forming cells to liver and gut in a fetal sheep model.

التفاصيل البيبلوغرافية
العنوان: Distinct contribution of human cord blood-derived endothelial colony forming cells to liver and gut in a fetal sheep model.
المؤلفون: Wood JA; Department of Animal Biotechnology, University of Nevada, Reno, NV, USA., Colletti E, Mead LE, Ingram D, Porada CD, Zanjani ED, Yoder MC, Almeida-Porada G
المصدر: Hepatology (Baltimore, Md.) [Hepatology] 2012 Sep; Vol. 56 (3), pp. 1086-96. Date of Electronic Publication: 2012 Aug 02.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [Philadelphia] : Wolters Kluwer Health, Inc.
Original Publication: Baltimore, MD : Williams & Wilkins, [c1981]-
مواضيع طبية MeSH: Cell Movement* , Fetal Blood*, Endothelial Cells/*physiology , Intestines/*cytology , Liver/*cytology, Animals ; Endothelial Cells/transplantation ; Humans ; Sheep
مستخلص: Unlabelled: Although the vasculogenic potential of circulating and cord blood (CB)-derived endothelial colony-forming cells (ECFC) has been demonstrated in vitro and in vivo, little is known about the inherent biologic ability of these cells to home to different organs and contribute to tissue-specific cell populations. Here we used a fetal sheep model of in utero transplantation to investigate and compare the intrinsic ability of human CB-derived ECFC to migrate to the liver and to the intestine, and to define ECFC's intrinsic ability to integrate and contribute to the cytoarchitecture of these same organs. ECFCs were transplanted by an intraperitoneal or intrahepatic route (IH) into fetal sheep at concentrations ranging from 1.1-2.6 × 10(6) cells/fetus. Recipients were evaluated at 85 days posttransplant for donor (human) cells using flow cytometry and confocal microscopy. We found that, regardless of the route of injection, and despite the IH delivery of ECFC, the overall liver engraftment was low, but a significant percentage of cells were located in the perivascular regions and retained the expression of hallmark endothelial makers. By contrast, ECFC migrated preferentially to the intestinal crypt region and contributed significantly to the myofibroblast population. Furthermore, ECFC expressing CD133 and CD117 lodged in areas where endogenous cells expressed those same phenotypes.
Conclusion: ECFC inherently constitute a potential source of cells for the treatment of intestinal diseases, but strategies to increase the numbers of ECFC persisting within the hepatic parenchyma are needed in order to enhance ECFC therapeutic potential for this organ.
(Copyright © 2012 American Association for the Study of Liver Diseases.)
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معلومات مُعتمدة: R01 HL097623-03 United States HL NHLBI NIH HHS; R01 HL073737-04 United States HL NHLBI NIH HHS; HL097623 United States HL NHLBI NIH HHS; HL073737 United States HL NHLBI NIH HHS; R01 HL073737 United States HL NHLBI NIH HHS; R01 HL097623 United States HL NHLBI NIH HHS
تواريخ الأحداث: Date Created: 20120411 Date Completed: 20121030 Latest Revision: 20211021
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC3396735
DOI: 10.1002/hep.25753
PMID: 22488442
قاعدة البيانات: MEDLINE
الوصف
تدمد:1527-3350
DOI:10.1002/hep.25753