دورية أكاديمية
Nanophotonic lab-on-a-chip platforms including novel bimodal interferometers, microfluidics and grating couplers.
| العنوان: | Nanophotonic lab-on-a-chip platforms including novel bimodal interferometers, microfluidics and grating couplers. |
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| المؤلفون: | Duval D; Nanobiosensors and Bioanalytical Applications Group (CIN2) CSIC and CIBER-BBN, Campus UAB, Barcelona, Spain., González-Guerrero AB, Dante S, Osmond J, Monge R, Fernández LJ, Zinoviev KE, Domínguez C, Lechuga LM |
| المصدر: | Lab on a chip [Lab Chip] 2012 May 08; Vol. 12 (11), pp. 1987-94. Date of Electronic Publication: 2012 Apr 27. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101128948 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-0189 (Electronic) Linking ISSN: 14730189 NLM ISO Abbreviation: Lab Chip Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, UK : Royal Society of Chemistry, c2001- |
| مواضيع طبية MeSH: | Lab-On-A-Chip Devices*, Interferometry/*instrumentation , Microfluidic Analytical Techniques/*instrumentation , Nanotechnology/*instrumentation , Optics and Photonics/*instrumentation, Antibodies/immunology ; Biosensing Techniques ; Humans ; Interferometry/methods ; Microfluidic Analytical Techniques/methods ; Nanotechnology/methods ; Optics and Photonics/methods ; Refractometry ; Thyrotropin/analysis ; Thyrotropin/immunology |
| مستخلص: | One of the main limitations for achieving truly lab-on-a-chip (LOC) devices for point-of-care diagnosis is the incorporation of the "on-chip" detection. Indeed, most of the state-of-the-art LOC devices usually require complex read-out instrumentation, losing the main advantages of portability and simplicity. In this context, we present our last advances towards the achievement of a portable and label-free LOC platform with highly sensitive "on-chip" detection by using nanophotonic biosensors. Bimodal waveguide interferometers fabricated by standard silicon processes have been integrated with sub-micronic grating couplers for efficient light in-coupling, showing a phase resolution of 6.6 × 10(-4)× 2π rad and a limit of detection of 3.3 × 10(-7) refractive index unit (RIU) in bulk. A 3D network of SU-8 polymer microfluidics monolithically assembled at the wafer-level was included, ensuring perfect sealing and compact packaging. To overcome some of the drawbacks inherent to interferometric read-outs, a novel all-optical wavelength modulation system has been implemented, providing a linear response and a direct read-out of the phase variation. Sensitivity, specificity and reproducibility of the wavelength modulated BiMW sensor has been demonstrated through the label-free immunodetection of the human hormone hTSH at picomolar level using a reliable biofunctionalization process. |
| المشرفين على المادة: | 0 (Antibodies) 9002-71-5 (Thyrotropin) |
| تواريخ الأحداث: | Date Created: 20120428 Date Completed: 20120910 Latest Revision: 20120614 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1039/c2lc40054e |
| PMID: | 22538502 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1473-0189 |
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| DOI: | 10.1039/c2lc40054e |