دورية أكاديمية
أعرض في EDS

Monitoring of pediatric patients with malignant hematological diseases after allogeneic HSCT: Serbian experience.

التفاصيل البيبلوغرافية
العنوان: Monitoring of pediatric patients with malignant hematological diseases after allogeneic HSCT: Serbian experience.
المؤلفون: Krstic AD; Mother and Child Health Care Institute, Dr Vukan Cupic, Belgrade, Serbia. alex.krstic@yahoo.com, Stojkovic O, Guc-Scekic M, Jevtic D, Zecevic Z, Vujic DS
المصدر: Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2012 Aug; Vol. 34 (6), pp. e253-7.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505928 Publication Model: Print Cited Medium: Internet ISSN: 1536-3678 (Electronic) Linking ISSN: 10774114 NLM ISO Abbreviation: J Pediatr Hematol Oncol Subsets: MEDLINE
أسماء مطبوعة: Publication: 1998- : Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: New York, NY : Raven Press, c1995-
مواضيع طبية MeSH: Hematopoietic Stem Cell Transplantation* , Monitoring, Physiologic*, Graft Rejection/*diagnosis , Hematologic Diseases/*genetics , Neoplasm Recurrence, Local/*diagnosis , Neoplasm, Residual/*diagnosis, Adolescent ; Child ; Child, Preschool ; Female ; Graft Rejection/genetics ; Graft Rejection/mortality ; Hematologic Diseases/mortality ; Hematologic Diseases/therapy ; Humans ; Male ; Microsatellite Repeats/genetics ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/mortality ; Neoplasm, Residual/genetics ; Neoplasm, Residual/mortality ; Polymerase Chain Reaction ; Prognosis ; Serbia ; Survival Rate ; Transplantation, Homologous
مستخلص: We describe the implementation of short tandem repeats-polymerase chain reaction (STR-PCR) chimerism analyses coupled with reverse transcription PCR detection of recurrent translocations characteristic for childhood leukemia in monitoring of patients after allogeneic hematopoietic stem cell transplantation in Serbia and the first clinical results thereof. Chimerism and minimal residual disease were regularly analyzed from blood and marrow samples of 26 pediatric patients taken after stem cell transplantation with a median follow-up of 17.6 months. Our results demonstrate that STR-based chimerism monitoring is sufficient in establishing the origin of engrafted cells after transplantation and in detecting graft rejection, but more specific and more sensitive method is necessary for identifying patients with threatening leukemia relapse.
تواريخ الأحداث: Date Created: 20120501 Date Completed: 20121002 Latest Revision: 20120719
رمز التحديث: 20221213
DOI: 10.1097/MPH.0b013e31824872bb
PMID: 22543520
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-3678
DOI:10.1097/MPH.0b013e31824872bb