دورية أكاديمية
Frequency of lower respiratory tract infections in relation to adaptive immunity in children with Down syndrome compared to their healthy siblings.
| العنوان: | Frequency of lower respiratory tract infections in relation to adaptive immunity in children with Down syndrome compared to their healthy siblings. |
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| المؤلفون: | Broers CJ; Department of Pediatrics, VU University Medical Center, Amsterdam, The Netherlands. ingemar.swenne@akademiska.se, Gemke RJ, Weijerman ME, Kuik DJ, van Hoogstraten IM, van Furth AM |
| المصدر: | Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2012 Aug; Vol. 101 (8), pp. 862-7. Date of Electronic Publication: 2012 May 02. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: Norway NLM ID: 9205968 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1651-2227 (Electronic) Linking ISSN: 08035253 NLM ISO Abbreviation: Acta Paediatr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2007- : Oslo : Wiley-Blackwell Original Publication: Oslo : Scandinavian University Press, c1992- |
| مواضيع طبية MeSH: | Adaptive Immunity*, Down Syndrome/*immunology , Respiratory Tract Infections/*immunology, Biomarkers/blood ; CD4-Positive T-Lymphocytes/metabolism ; Case-Control Studies ; Child ; Down Syndrome/complications ; Female ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/immunology ; Hospitalization/statistics & numerical data ; Humans ; Immunoglobulin G/blood ; Lymphocyte Count ; Male ; Natural Killer T-Cells/metabolism ; Respiratory Tract Infections/complications ; Respiratory Tract Infections/epidemiology ; Siblings |
| مستخلص: | Aim: Children with Down syndrome (DS) experience respiratory tract infections (RTIs) more frequently than healthy children. We investigated whether this is related to different immunological characteristics associated with DS. Methods: The study group consisted of 22 children with DS and 22 of their healthy, age-range matched siblings. Data were collected on infections and hospitalizations because of lower RTIs. Immunoglobulin and IgG subclass levels in blood, as well as lymphocyte and T cell (subset) counts, were determined. Results: The children with DS had a significantly higher frequency of lower RTIs and related hospitalization than their siblings. We also found significantly reduced IgG2 levels as well as significantly lower counts of total lymphocytes, CD4(+) T lymphocytes, CD4(+) invariant natural killer (iNKT) cells and regulatory T cells in the DS group. Conclusion: In children with DS, reduced levels of IgG2, total lymphocytes, T lymphocytes, iNKT cells and regulatory T cells might contribute to their higher susceptibility to lower RTIs. (© 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.) |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Immunoglobulin G) |
| تواريخ الأحداث: | Date Created: 20120503 Date Completed: 20121105 Latest Revision: 20151119 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/j.1651-2227.2012.02696.x |
| PMID: | 22548641 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1651-2227 |
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| DOI: | 10.1111/j.1651-2227.2012.02696.x |