دورية أكاديمية
Differentiation of mesenchymal stem cell in the microenviroment of retinitis pigmentosa.
| العنوان: | Differentiation of mesenchymal stem cell in the microenviroment of retinitis pigmentosa. |
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| المؤلفون: | Huo DM; Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China., Dong FT, Yu WH, Gao F |
| المصدر: | International journal of ophthalmology [Int J Ophthalmol] 2010; Vol. 3 (3), pp. 216-9. Date of Electronic Publication: 2010 Sep 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Press of International Journal of Ophthalmology Country of Publication: China NLM ID: 101553860 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2222-3959 (Print) Linking ISSN: 22223959 NLM ISO Abbreviation: Int J Ophthalmol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Xi'an, China : Press of International Journal of Ophthalmology |
| مستخلص: | Unlabelled: CORRESPONDENCE TO: Fang-Tian Dong. Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. d_fangtian@sina.com Aim: To access the differentiation of rat mesenchymal stem cell (MSC) in the microenvironment of retinal degeneration induced by the administration of sodium iodate. Methods: In-vitro cultured Lewis rat MSC were injected into the sub-retinal space of NaIO(3) induced retinal degeneration rat eyes (30g/L NaIO(3) 100mg/kg). To observe the trace and differentiation of MSC by immuno-fluorescent method successively in 5 weeks after the surgery. Results: The majority of the transplanted cells stay in retinal pigment epithelium layer and cones & rods layer. From the 2(nd) week after transplantation, the engrafted MSC express PCK and rhodopsin under fluorescent microscope. Conclusion: MSC can survive mainly in the outer layer of retina in the microenvironment of retinal degeneration and differentiate forward the RPE cell and photoreceptor. |
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| فهرسة مساهمة: | Keywords: NaIO3; differentiation; mesenchymal stem cell; retinal degeneration; transplantation in subretinal space |
| تواريخ الأحداث: | Date Created: 20120504 Date Completed: 20120823 Latest Revision: 20211021 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC3340632 |
| DOI: | 10.3980/j.issn.2222-3959.2010.03.08 |
| PMID: | 22553557 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2222-3959 |
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| DOI: | 10.3980/j.issn.2222-3959.2010.03.08 |