دورية أكاديمية

Double-blind, randomised clinical assay to evaluate the efficacy of probiotics in preterm newborns weighing less than 1500 g in the prevention of necrotising enterocolitis.

التفاصيل البيبلوغرافية
العنوان: Double-blind, randomised clinical assay to evaluate the efficacy of probiotics in preterm newborns weighing less than 1500 g in the prevention of necrotising enterocolitis.
المؤلفون: Fernández-Carrocera LA; Neonatology Department, Instituto Nacional de Perinatología, Montes Urales 800 CP 11000, México., Solis-Herrera A, Cabanillas-Ayón M, Gallardo-Sarmiento RB, García-Pérez CS, Montaño-Rodríguez R, Echániz-Aviles MO
المصدر: Archives of disease in childhood. Fetal and neonatal edition [Arch Dis Child Fetal Neonatal Ed] 2013 Jan; Vol. 98 (1), pp. F5-9. Date of Electronic Publication: 2012 May 03.
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: British Medical Association Country of Publication: England NLM ID: 9501297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2052 (Electronic) Linking ISSN: 13592998 NLM ISO Abbreviation: Arch Dis Child Fetal Neonatal Ed Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : British Medical Association,
مواضيع طبية MeSH: Infant, Very Low Birth Weight*, Enterocolitis, Necrotizing/*prevention & control , Probiotics/*therapeutic use, Double-Blind Method ; Female ; Humans ; Infant, Newborn ; Infant, Premature ; Male ; Treatment Outcome
مستخلص: Background: A randomised, double-blind clinical trial was undertaken in order to assess the effectiveness of probiotics in the prevention of necrotising enterocolitis (NEC) in newborns weighing <1500 g.
Methods: We studied a group of 150 patients who were randomised in two groups after parental consent was obtained, to receive either a daily feeding supplementation with a multispecies probiotic (Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus casei, Lactobacillus plantarum, Bifidobacteruim infantis, Streptococcus thermophillus) 1 g per day plus their regular feedings or to receive their regular feedings with nothing added (control group), over the period of January 2007 through June 2010. Clinicians in care of the infants were blinded to the group assignment.
Results: The primary outcome was the development of NEC. Both groups were comparable, with no differences during hospitalisation, including the type of nutrition received. Blood cultures obtained from cases that developed sepsis did not reveal lactobacillus or Bifidobacteria growth. No differences were detected in terms of NEC risk reduction (RR: 0.54, 95% CI 0.21 to 1.39) although we did observe a clear trend in the reduction of NEC frequency in the studied cases: 6 (8%) versus 12 (16%) in the control group. When the combined risk of NEC or death was calculated as a post hoc analysis, we found a significantly lower risk (RR: 0.39, 95% CI 0.17 to 0.87) for the study group.
Conclusions: Probiotics may offer potential benefits for premature infants and are a promising strategy in the reduction of the risk of NEC in preterm newborns.
التعليقات: Comment in: Evid Based Med. 2013 Dec;18(6):219-20. (PMID: 23604182)
تواريخ الأحداث: Date Created: 20120505 Date Completed: 20130221 Latest Revision: 20220330
رمز التحديث: 20221213
DOI: 10.1136/archdischild-2011-300435
PMID: 22556209
قاعدة البيانات: MEDLINE
الوصف
تدمد:1468-2052
DOI:10.1136/archdischild-2011-300435