دورية أكاديمية
Lack of effect of pinacidil on theophylline pharmacokinetics and metabolism in man.
| العنوان: | Lack of effect of pinacidil on theophylline pharmacokinetics and metabolism in man. |
|---|---|
| المؤلفون: | Nielsen-Kudsk JE; Department of Internal Medicine, Silkeborg General Hospital, Denmark., Nielsen CB, Mellemkjaer S, Siggaard C |
| المصدر: | Pharmacology & toxicology [Pharmacol Toxicol] 1990 Aug; Vol. 67 (2), pp. 156-8. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nordic Pharmacological Society Country of Publication: Denmark NLM ID: 8702180 Publication Model: Print Cited Medium: Print ISSN: 0901-9928 (Print) Linking ISSN: 09019928 NLM ISO Abbreviation: Pharmacol Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: -2003: [Copenhagen, Denmark] : Nordic Pharmacological Society : Distributed by Blackwell Munksgaard Original Publication: Copenhagen, Denmark : Nordic Pharmacological Society ; Distributor, Munksgaard, c1987-c2003. |
| مواضيع طبية MeSH: | Antihypertensive Agents/*pharmacology , Guanidines/*pharmacology , Theophylline/*pharmacokinetics , Vasodilator Agents/*pharmacology, Administration, Oral ; Adult ; Female ; Guanidines/administration & dosage ; Half-Life ; Humans ; Male ; Metabolic Clearance Rate ; Pinacidil ; Theophylline/blood ; Theophylline/urine |
| مستخلص: | Pinacidil, a pyridyl cyanoguanidine derivative, is a new antihypertensive vasodilator drug. It shares structural similarities with the histamine H2-receptor blocker cimetidine, an imidazole cyanoguanidine derivative, which is a potent inhibitor of cytochrome P-450 and of theophylline metabolism. In the present study the pharmacokinetics and metabolism of theophylline were determined in six healthy volunteers before and on the last day of oral pinacidil administration for two weeks. The dosage of pinacidil was 12.5 mg twice a day in the first week and 25 mg in the second. There were no significant changes in theophylline plasma clearance, terminal half-life or volume of distribution during pinacidil administration. Also the renal and metabolic clearance of theophylline and the formation clearances of the major theophylline metabolites in the urine (DMU, 1MU, 3MX) did not change significantly during administration of therapeutic doses of pinacidil. |
| المشرفين على المادة: | 0 (Antihypertensive Agents) 0 (Guanidines) 0 (Vasodilator Agents) 7B0ZZH8P2W (Pinacidil) C137DTR5RG (Theophylline) |
| تواريخ الأحداث: | Date Created: 19900801 Date Completed: 19910124 Latest Revision: 20190903 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/j.1600-0773.1990.tb00803.x |
| PMID: | 2255669 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0901-9928 |
|---|---|
| DOI: | 10.1111/j.1600-0773.1990.tb00803.x |