التفاصيل البيبلوغرافية
| العنوان: |
Multiple sclerosis: risk factors and their interactions. |
| المؤلفون: |
Disanto G; Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, UK., Morahan JM, Ramagopalan SV |
| المصدر: |
CNS & neurological disorders drug targets [CNS Neurol Disord Drug Targets] 2012 Aug; Vol. 11 (5), pp. 545-55. |
| نوع المنشور: |
Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101269155 Publication Model: Print Cited Medium: Internet ISSN: 1996-3181 (Electronic) Linking ISSN: 18715273 NLM ISO Abbreviation: CNS Neurol Disord Drug Targets Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Saif Zone, Sharjah, U.A.E.; San Francisco, CA : Bentham Science Publishers, c2006- |
| مواضيع طبية MeSH: |
Multiple Sclerosis/*epidemiology, Adolescent ; Adult ; Child ; Epstein-Barr Virus Infections/physiopathology ; Genetic Predisposition to Disease ; Humans ; Multiple Sclerosis/etiology ; Multiple Sclerosis/genetics ; Multiple Sclerosis/prevention & control ; Risk Factors ; Seasons ; Smoking/adverse effects ; Vitamin D Deficiency/physiopathology |
| مستخلص: |
Multiple sclerosis (MS) is a highly debilitating immune mediated disorder of the central nervous system and represents a substantial burden to the developed world. Despite the recent advances in MS research, which risk factors are implicated and how they contribute to MS pathogenesis is largely unknown. However, in line with older studies investigating the genetic and geographical epidemiology of this complex disease, more recent studies have highlighted how MS arises from a combination of genetic susceptibility and environmental exposures acting from gestation to early adulthood. Vitamin D deficiency, season of birth, Epstein Barr virus infection, and smoking behaviour are strongly implicated and able to influence genetic predisposition to MS. Furthermore, these factors appear to act synergistically and the risk of MS in individuals exposed to more than one factor combines multiplicatively. Current evidence suggests that a large part of MS could be prevented and understanding how and when during life risk factors act will ultimately aid the development of prevention strategies. |
| معلومات مُعتمدة: |
090532/Z/09/Z United Kingdom Wellcome Trust; G0801976 United Kingdom Medical Research Council |
| تواريخ الأحداث: |
Date Created: 20120516 Date Completed: 20121119 Latest Revision: 20220321 |
| رمز التحديث: |
20231215 |
| DOI: |
10.2174/187152712801661266 |
| PMID: |
22583442 |
| قاعدة البيانات: |
MEDLINE |
