دورية أكاديمية
[Blood plasma protein adsorption capacity of perfluorocarbon emulsion stabilized by proxanol 268 (in vitro and in vivo studies)].
| العنوان: | [Blood plasma protein adsorption capacity of perfluorocarbon emulsion stabilized by proxanol 268 (in vitro and in vivo studies)]. |
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| المؤلفون: | Sklifas AN, Zhalimov VK, Temnov AA, Kukushkin NI |
| المصدر: | Biofizika [Biofizika] 2012 Mar-Apr; Vol. 57 (2), pp. 317-24. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izdatelstvo Nauka Country of Publication: Russia (Federation) NLM ID: 0372666 Publication Model: Print Cited Medium: Print ISSN: 0006-3029 (Print) Linking ISSN: 00063029 NLM ISO Abbreviation: Biofizika Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Izdatelstvo Nauka |
| مواضيع طبية MeSH: | Blood Proteins*/chemistry , Blood Proteins*/metabolism , Blood Substitutes*/chemistry , Blood Substitutes*/pharmacokinetics , Blood Substitutes*/pharmacology , Fluorocarbons*/chemistry , Fluorocarbons*/pharmacokinetics , Fluorocarbons*/pharmacology , Poloxalene*/chemistry , Poloxalene*/pharmacokinetics , Poloxalene*/pharmacology , Surface-Active Agents*/chemistry , Surface-Active Agents*/pharmacokinetics , Surface-Active Agents*/pharmacology, Adsorption ; Animals ; Emulsions/chemistry ; Emulsions/pharmacokinetics ; Emulsions/pharmacology ; Humans ; Hydrophobic and Hydrophilic Interactions ; Rabbits |
| مستخلص: | The adsorption abilities of the perfluorocarbon emulsion stabilized by Proxanol 268 were investigated in vitro and in vivo. In vitro, the saturation point for the blood plasma proteins was nearly reached after five minutes of incubation of the emulsion with human/rabbit blood plasma and was stable for all incubation periods studied. The decrease in volume ratio (emulsion/plasma) was accompanied by the increase in the adsorptive capacity of the emulsion with maximal values at 1/10 (3.2 and 1.5 mg of proteins per 1 ml of the emulsion, for human and rabbit blood plasma, respectively) that was unchanged at lower ratios. In vivo, in rabbits, intravenously injected with the emulsion, the proteins with molecular masses of 12, 25, 32, 44, 55, 70, and 200 kDa were adsorbed by the emulsion (as in vitro) if it was used 6 hours or less before testing. More delayed testing (6 h) revealed elimination of proteins with molecular masses of 25 and 44 kDa and an additional pool of adsorpted new ones of 27, 50, and 150 kDa. Specific adsorptive capacity of the emulsion enhanced gradually after emulsion injection and reached its maximum (3.5-5 mg of proteins per 1 ml of the emulsion) after 24 hours. |
| المشرفين على المادة: | 0 (Blood Proteins) 0 (Blood Substitutes) 0 (Emulsions) 0 (Fluorocarbons) 0 (Surface-Active Agents) 9003-11-6 (Poloxalene) |
| تواريخ الأحداث: | Date Created: 20120519 Date Completed: 20120608 Latest Revision: 20120518 |
| رمز التحديث: | 20231215 |
| PMID: | 22594289 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0006-3029 |
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