دورية أكاديمية
Oncogene-mediated alterations in chromatin conformation.
| العنوان: | Oncogene-mediated alterations in chromatin conformation. |
|---|---|
| المؤلفون: | Rickman DS; Department of Pathology and Laboratory Medicine, HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY 10065, USA., Soong TD, Moss B, Mosquera JM, Dlabal J, Terry S, MacDonald TY, Tripodi J, Bunting K, Najfeld V, Demichelis F, Melnick AM, Elemento O, Rubin MA |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2012 Jun 05; Vol. 109 (23), pp. 9083-8. Date of Electronic Publication: 2012 May 21. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Nucleic Acid Conformation*, Chromatin Assembly and Disassembly/*genetics , Trans-Activators/*metabolism, Base Sequence ; Cell Line ; Chromatin Immunoprecipitation ; DNA Primers/genetics ; Flow Cytometry ; High-Throughput Nucleotide Sequencing ; Humans ; In Situ Hybridization, Fluorescence ; Karyotyping ; Molecular Sequence Data ; Reverse Transcriptase Polymerase Chain Reaction ; Transcriptional Regulator ERG |
| مستخلص: | Emerging evidence suggests that chromatin adopts a nonrandom 3D topology and that the organization of genes into structural hubs and domains affects their transcriptional status. How chromatin conformation changes in diseases such as cancer is poorly understood. Moreover, how oncogenic transcription factors, which bind to thousands of sites across the genome, influence gene regulation by globally altering the topology of chromatin requires further investigation. To address these questions, we performed unbiased high-resolution mapping of intra- and interchromosome interactions upon overexpression of ERG, an oncogenic transcription factor frequently overexpressed in prostate cancer as a result of a gene fusion. By integrating data from genome-wide chromosome conformation capture (Hi-C), ERG binding, and gene expression, we demonstrate that oncogenic transcription factor overexpression is associated with global, reproducible, and functionally coherent changes in chromatin organization. The results presented here have broader implications, as genomic alterations in other cancer types frequently give rise to aberrant transcription factor expression, e.g., EWS-FLI1, c-Myc, n-Myc, and PML-RARα. |
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| معلومات مُعتمدة: | R01 CA104348 United States CA NCI NIH HHS; R01 CA125612 United States CA NCI NIH HHS; R01 CA179100 United States CA NCI NIH HHS; CA125612 United States CA NCI NIH HHS |
| سلسلة جزيئية: | GEO GSE37752 |
| المشرفين على المادة: | 0 (DNA Primers) 0 (ERG protein, human) 0 (Trans-Activators) 0 (Transcriptional Regulator ERG) |
| تواريخ الأحداث: | Date Created: 20120523 Date Completed: 20120827 Latest Revision: 20220311 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC3384175 |
| DOI: | 10.1073/pnas.1112570109 |
| PMID: | 22615383 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1091-6490 |
|---|---|
| DOI: | 10.1073/pnas.1112570109 |