دورية أكاديمية
أعرض في EDS

Vitamin B(12) Deficiency and Multiple Sclerosis; Is there Any Association?

التفاصيل البيبلوغرافية
العنوان: Vitamin B(12) Deficiency and Multiple Sclerosis; Is there Any Association?
المؤلفون: Najafi MR; Department of Neurology and Isfahan Neuroscience Research Center, Isfahan, Iran., Shaygannajad V, Mirpourian M, Gholamrezaei A
المصدر: International journal of preventive medicine [Int J Prev Med] 2012 Apr; Vol. 3 (4), pp. 286-9.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Isfahan University of Medical Sciences Country of Publication: Iran NLM ID: 101535380 Publication Model: Print Cited Medium: Internet ISSN: 2008-8213 (Electronic) Linking ISSN: 20087802 NLM ISO Abbreviation: Int J Prev Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Isfahan : Isfahan University of Medical Sciences, 2010-
مستخلص: Background: Vitamin B(12) (Cobalamin) deficiency can result in some clinical and paraclinical characteristics similar to what is seen in multiple sclerosis (MS) patients. This study aimed to evaluate the controversial association between vitamin B(12) deficiency and MS.
Methods: We measured serum vitamin B(12) in 60 patients with MS and 38 healthy controls. Clinical disability was evaluated according to the Extended Disability Status Scale (EDSS). Serum B(12) concentration was measured with Radioimmunoassay Dual Isotope method. The cutoff value for low serum vitamin B(12) concentrations was 75 pg/mL. Patients were in remission at the time of blood draw.
Results: There were 13 (21.6%) MS patients and 10 (26.3%) controls with low serum B(12) concentration with no significant difference between the groups; P>0.05. The mean serum vitamin B(12) concentration in MS patients (108.9±45.3 pg/mL) was not significantly different compared with controls (98.9±44.4 pg/mL); P=0.284. Likewise, there was no correlation between the concentration of serum vitamin B(12) and disease' age of onset, duration, subtypes, or disability status.
Conclusions: In contrast to some previous reports, our findings did not support any association between B(12) deficiency and MS.
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فهرسة مساهمة: Keywords: Cobalamin; multiple sclerosis; vitamin B12
تواريخ الأحداث: Date Created: 20120525 Date Completed: 20121002 Latest Revision: 20211021
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3354399
PMID: 22624086
قاعدة البيانات: MEDLINE
الوصف
تدمد:2008-8213