دورية أكاديمية
[Stereotactic radiotherapy and radiosurgery in treatment of patients with deep-seated pilocytic astrocytomas].
| العنوان: | [Stereotactic radiotherapy and radiosurgery in treatment of patients with deep-seated pilocytic astrocytomas]. |
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| المؤلفون: | Trunin IuIu, Golanov AV, Konovalov AN, Shishkina LV, Gorlachev GE, Gorelyshev SK, Pronin IN, Khukhlaeva EA, Serova NK, Korshunov AG, Melikian AG, Ryzhova MV, Kadyrov ShU, Sorokin VS, Mazerkina NA, Mariashev SA, Il'ialov SR, Kostiuchenko VV |
| المصدر: | Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko [Zh Vopr Neirokhir Im N N Burdenko] 2012; Vol. 76 (1), pp. 64-78; discussion 78. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Media Sfera Country of Publication: Russia (Federation) NLM ID: 7809757 Publication Model: Print Cited Medium: Print ISSN: 0042-8817 (Print) Linking ISSN: 00428817 NLM ISO Abbreviation: Zh Vopr Neirokhir Im N N Burdenko Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Moskva : Media Sfera Original Publication: Moskva, Meditsina. |
| مواضيع طبية MeSH: | Neuronavigation*/instrumentation , Neuronavigation*/methods , Radiosurgery*/instrumentation , Radiosurgery*/methods, Astrocytoma/*surgery , Brain Neoplasms/*surgery, Adult ; Astrocytoma/diagnostic imaging ; Astrocytoma/pathology ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/pathology ; Child ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging ; Male ; Radiography ; Treatment Outcome ; Young Adult |
| مستخلص: | Pilocytic astrocytoma (PA) is a low-grade glial tumor (WHO grade I) with predominant occurrence in pediatric patients. According to many authors, stereotactic radiosurgery (SRS) and radiotherapy (SRT) promote long-term remission or retardation of tumor progression in patients with in inoperable lesions after incomplete resection or recurrence. Therefore it is essential to determine the role of SRS and SRT in complex management of patients with deep-seated PA. Since April 2005 till May 2010 101 patient with intracranial PA was treated in department for radiation therapy of Burdenko Neurosurgical Institute. The series consisted of 70 pediatric patients (below 17 years inclusively) and 31 adults, of them--51 male and 50 female patients. Mean age was 15.1 years (9.8 years in children and 28.7 in adults). In 90 patients (89.2%) tumors were previously histologically verified (tumor resection in 83 cases and biopsy in 7). In 11 (10.8%) patients diagnosis of PA was based on clinical and neurovisualization data. In most cases SRT (66 (66.3%) patients) was preformed, the rest 35 (34.7%) patients were treated by SRS. Median follow-up from the onset of disease reached 52 months (2-228 months). Catamnestic data were available in 88 (87%) patients. By the end of catamnestic follow-up (December 2010) 87 (98.8%) patients treated by SRS and SRT were alive. Median follow-up from the start of radiation treatment was 22.7 months (6-60 months). Progression of tumor was observed in 20 patients (22.7%), in 18 of them due to cyst growth. 18 patients were reoperated. In 12 operated patients histological examination and its comparative analysis were performed. We found that alterations in the tumor tissue, accompanied by regression of solid component and progression of cystic portion, represent reactive-degenerative changes in the tumor as a consequence of radiation-induced pathomorphism. SRS and STR are effective techniques for treatment of patients with primary and recurrent PA despite regardless of localization of the tumor. There procedures should be performed shortly after non-radical resection. Control of tumor growth by the present time (median follow-up is 22.7 months) reaches 98%. "Progression" of the tumor due to enlargement of cystic portion shortly after SRT and SRS represents reactive-degenerative alterations in the tumor tissue and should not be evaluated as true recurrence; without neurological deterioration these cases do not require special treatment. |
| تواريخ الأحداث: | Date Created: 20120529 Date Completed: 20120703 Latest Revision: 20161125 |
| رمز التحديث: | 20240628 |
| PMID: | 22629849 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0042-8817 |
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