دورية أكاديمية

Carotid chemoreceptor development in mice.

التفاصيل البيبلوغرافية
العنوان: Carotid chemoreceptor development in mice.
المؤلفون: Shirahata M; Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA. mshiraha@jhsph.edu, Kostuk EW, Pichard LE
المصدر: Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2013 Jan 01; Vol. 185 (1), pp. 20-9. Date of Electronic Publication: 2012 May 24.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101140022 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1519 (Electronic) Linking ISSN: 15699048 NLM ISO Abbreviation: Respir Physiol Neurobiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; New York : Elsevier Science, c2002-
مواضيع طبية MeSH: Carotid Body/*growth & development , Carotid Body/*physiology, Animals ; Chemoreceptor Cells/cytology ; Chemoreceptor Cells/physiology ; Mice ; Mice, Knockout
مستخلص: Mice are the most suitable species for understanding genetic aspects of postnatal developments of the carotid body due to the availability of many inbred strains and knockout mice. Our study has shown that the carotid body grows differentially in different mouse strains, indicating the involvement of genes. However, the small size hampers investigating functional development of the carotid body. Hypoxic and/or hyperoxic ventilatory responses have been investigated in newborn mice, but these responses are indirect assessment of the carotid body function. Therefore, we need to develop techniques of measuring carotid chemoreceptor neural activity from young mice. Many studies have taken advantage of the knockout mice to understand chemoreceptor function of the carotid body, but they are not always suitable for addressing postnatal development of the carotid body due to lethality during perinatal periods. Various inbred strains with well-designed experiments will provide useful information regarding genetic mechanisms of the postnatal carotid chemoreceptor development. Also, targeted gene deletion is a critical approach.
(Copyright © 2012 Elsevier B.V. All rights reserved.)
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معلومات مُعتمدة: F31 HL096450 United States HL NHLBI NIH HHS; R01 HL081345 United States HL NHLBI NIH HHS; HL81345 United States HL NHLBI NIH HHS; F31HL096450 United States HL NHLBI NIH HHS
تواريخ الأحداث: Date Created: 20120529 Date Completed: 20130722 Latest Revision: 20211021
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC3442145
DOI: 10.1016/j.resp.2012.05.017
PMID: 22634368
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-1519
DOI:10.1016/j.resp.2012.05.017