دورية أكاديمية
Glomerulitis and endothelial cell enlargement in C4d+ and C4d- acute rejections of renal transplant patients.
| العنوان: | Glomerulitis and endothelial cell enlargement in C4d+ and C4d- acute rejections of renal transplant patients. |
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| المؤلفون: | Aiello FB; Department of Medicine and Aging Science, University of Chieti, 66100 Chieti, Italy., Furian L, Della Barbera M, Marino S, Seveso M, Cardillo M, Pierobon ES, Cozzi E, Rigotti P, Valente M |
| المصدر: | Human pathology [Hum Pathol] 2012 Dec; Vol. 43 (12), pp. 2157-66. Date of Electronic Publication: 2012 May 29. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: W B Saunders Country of Publication: United States NLM ID: 9421547 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8392 (Electronic) Linking ISSN: 00468177 NLM ISO Abbreviation: Hum Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Philadelphia, PA : W B Saunders Original Publication: Philadelphia, W B. Saunders Co. |
| مواضيع طبية MeSH: | Complement C4b/*immunology , Endothelial Cells/*pathology , Glomerulonephritis/*pathology , Graft Rejection/*pathology , Kidney Transplantation/*pathology , Peptide Fragments/*immunology, Adult ; Aged ; Cell Enlargement ; Endothelial Cells/immunology ; Female ; Follow-Up Studies ; Glomerulonephritis/immunology ; Graft Rejection/immunology ; Humans ; Kidney Glomerulus/immunology ; Kidney Glomerulus/pathology ; Kidney Transplantation/immunology ; Male ; Middle Aged |
| مستخلص: | In acute rejection after renal transplant, glomerulitis is characterized by mononuclear cells in glomerular capillaries and endothelial cell enlargement. In association with C4d deposition in peritubular capillaries, glomerulitis is a feature of acute antibody-mediated rejection. Prognosis in C4d(+) rejection is poorer than in C4d(-) rejection. We measured the glomerular endothelial cell area in C4d(+) and C4d(-) acute rejections by morphometry. In 90 acute rejection biopsies, glomerulitis was present in 36 cases (group G) and absent in 54 (group G0). In biopsies without rejections and in C4d(-) biopsies of group G0, glomerular endothelial cell area was not significantly different. In C4d(-) and C4d(+) biopsies of group G, the area in inflamed glomeruli was greater than that in C4d(-) biopsies of group G0 (P < .02 and P < .006, respectively). In C4d(+) biopsies of group G0, it was, unexpectedly, greater than in C4d(-) biopsies of group G (P < .01). Circulating posttransplant anti-human leukocyte antigen class I and class II antibodies correlated with increased endothelial cell area (P < .02). Glomerulitis was associated with diffuse C4d deposition (odds ratio [OR], 4.27; P < .004); C4d deposition was associated with steroid resistance (OR, 4.97; P < .002). Only in C4d(+) rejections did the presence of glomerulitis increase this association (OR, 9.17; P < .02). In conclusion, we quantified an increase of endothelial cell area in glomerulitis of C4d(+) and C4d(-) acute rejections (group G). An increase of this area in C4d(+) biopsies without glomerulitis (group G0) suggests complement-mediated damage in the absence of mononuclear cell margination. (Copyright © 2012 Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 0 (Peptide Fragments) 80295-50-7 (Complement C4b) 80295-52-9 (complement C4d) |
| تواريخ الأحداث: | Date Created: 20120601 Date Completed: 20130205 Latest Revision: 20121119 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.humpath.2012.02.019 |
| PMID: | 22647352 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-8392 |
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| DOI: | 10.1016/j.humpath.2012.02.019 |