دورية أكاديمية
Phytochemical and biological investigations of Atriplex semibacata R .BR. growing in Egypt.
| العنوان: | Phytochemical and biological investigations of Atriplex semibacata R .BR. growing in Egypt. |
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| المؤلفون: | Tawfik WA; Phytochemistry Dept., NRC, Dokki, Cairo, Egypt, 12311. wafaatawfik1@yahoo.com, Abdel-Mohsen MM, Radwan HM, Habib AA, Yeramian MA |
| المصدر: | African journal of traditional, complementary, and alternative medicines : AJTCAM [Afr J Tradit Complement Altern Med] 2011; Vol. 8 (4), pp. 435-43. Date of Electronic Publication: 2011 Jun 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: African Traditional Herbal Medicine Supporters Initiative Country of Publication: Nigeria NLM ID: 101232990 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2505-0044 (Electronic) Linking ISSN: 25050044 NLM ISO Abbreviation: Afr J Tradit Complement Altern Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Osun : African Traditional Herbal Medicine Supporters Initiative Original Publication: [Ile-Ife, Nigeria? : African Networks on Ethnomedicines, 2004]- |
| مواضيع طبية MeSH: | Atriplex/*chemistry , Coumarins/*isolation & purification , Flavonoids/*isolation & purification , Lipids/*isolation & purification , Plant Extracts/*chemistry , Plant Extracts/*pharmacology, Animals ; Anti-Infective Agents/pharmacology ; Antifungal Agents/pharmacology ; Antineoplastic Agents/pharmacology ; Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Bacteria/drug effects ; Carcinoma, Ehrlich Tumor/drug therapy ; Coumarins/pharmacology ; Egypt ; Flavonoids/pharmacology ; Fungi/drug effects ; Gas Chromatography-Mass Spectrometry ; Lipids/pharmacology ; Microbial Sensitivity Tests |
| مستخلص: | The lipid content of Atriplex semibacata growing in Egypt was studied. The unsaponifiable fraction was identified by GLC. A series of hydrocarbons ranging from C(14)- C(28) in addition to cholesterol, stigmasterol and the triterpenoids α and β - amyrin were identified. GLC analysis of fatty alcohols fraction revealed the presence of six fatty alcohols in which dotriacontanol (C(32)H(66)O) was the major (14.68%). Six compounds (five coumarins and one phenolic acid) were isolated for the first time from A. semibacata. The coumarin constituents isolated from the chloroform and the ethyl acetate fractions of the aqueous alcoholic extract of A. semibacata were identified as scopoletin, umbelliferorne, coumarin, scopolin, 7-methoxy coumarin in addition to a phenolic acid P-coumaric acid. Also, the flavonoidal compounds isolated from the n-butanol fraction of the plant revealed the presence of kaempferol 3-O glucoside and acacetin. Their identity was proved by m.p., TLC, PC, UV and MS analysis. The alcohol extract showed significant antimicrobial activity against G-ve bacteria, moderate activity against G+ve bacteria. On the other hand, the pet. Ether extract showed marked activity against G+ve bacteria and fungi, also the G-ve bacteria was greatly inhibited by the chloroform extract. The different extracts of the plant exhibited no cytotoxic activity against Erlich-ascites carcinoma cells line at the tested concentrations, also showed a strong antioxidant activity using DPPH. |
| References: | Yao Xue Xue Bao. 2002 May;37(5):348-51. (PMID: 12579838) Zhongguo Zhong Yao Za Zhi. 1999 Mar;24(3):160-1, 191. (PMID: 12242798) Arch Latinoam Nutr. 1988 Dec;38(4):844-51. (PMID: 3154295) Fitoterapia. 2000 Dec;71(6):627-9. (PMID: 11077167) Biosci Biotechnol Biochem. 1998 Jun;62(6):1201-4. (PMID: 9692204) Z Naturforsch C J Biosci. 2003 Jul-Aug;58(7-8):485-9. (PMID: 12939032) J Egypt Soc Parasitol. 1987 Dec;17(2):539-46. (PMID: 3693953) J Ethnopharmacol. 1987 Mar-Apr;19(2):145-51. (PMID: 3613607) |
| فهرسة مساهمة: | Keywords: Atriplex semibacata; antifungal; antimicrobial; antioxidant; antitumor; coumarins; fatty alcohols; flavonoids; unsaponifiable fraction |
| المشرفين على المادة: | 0 (Anti-Infective Agents) 0 (Antifungal Agents) 0 (Antineoplastic Agents) 0 (Antioxidants) 0 (Coumarins) 0 (Flavonoids) 0 (Lipids) 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20120602 Date Completed: 20121026 Latest Revision: 20211021 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC3218464 |
| DOI: | 10.4314/ajtcam.v8i4.15 |
| PMID: | 22654223 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2505-0044 |
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| DOI: | 10.4314/ajtcam.v8i4.15 |