دورية أكاديمية
Actin network architecture can determine myosin motor activity.
| العنوان: | Actin network architecture can determine myosin motor activity. |
|---|---|
| المؤلفون: | Reymann AC; Institut de Recherches en Technologies et Sciences pour le Vivant (iRTSV), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA)-Institut National de la Recherche Agronomique (INRA), Grenoble, France., Boujemaa-Paterski R, Martiel JL, Guérin C, Cao W, Chin HF, De La Cruz EM, Théry M, Blanchoin L |
| المصدر: | Science (New York, N.Y.) [Science] 2012 Jun 08; Vol. 336 (6086), pp. 1310-4. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: New York, N.Y. : [s.n.] 1880- |
| مواضيع طبية MeSH: | Actin Cytoskeleton/*metabolism , Actin Cytoskeleton/*ultrastructure , Actins/*metabolism , Myosin Heavy Chains/*metabolism , Myosin Type II/*metabolism, Actins/chemistry ; Actomyosin/chemistry ; Actomyosin/metabolism ; Animals ; Myosin Heavy Chains/chemistry ; Myosin Type II/chemistry ; Rabbits ; Swine |
| مستخلص: | The organization of actin filaments into higher-ordered structures governs eukaryotic cell shape and movement. Global actin network size and architecture are maintained in a dynamic steady state through regulated assembly and disassembly. Here, we used experimentally defined actin structures in vitro to investigate how the activity of myosin motors depends on network architecture. Direct visualization of filaments revealed myosin-induced actin network deformation. During this reorganization, myosins selectively contracted and disassembled antiparallel actin structures, while parallel actin bundles remained unaffected. The local distribution of nucleation sites and the resulting orientation of actin filaments appeared to regulate the scalability of the contraction process. This "orientation selection" mechanism for selective contraction and disassembly suggests how the dynamics of the cellular actin cytoskeleton can be spatially controlled by actomyosin contractility. |
| References: | J Cell Biol. 1997 Oct 20;139(2):397-415. (PMID: 9334344) Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15192-7. (PMID: 19667200) Methods Cell Biol. 1982;24:333-71. (PMID: 6212751) Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9685-90. (PMID: 19478066) Cell. 2003 Feb 21;112(4):453-65. (PMID: 12600310) Cytoskeleton (Hoboken). 2010 Nov;67(11):693-705. (PMID: 20814909) Nature. 2010 May 20;465(7296):373-7. (PMID: 20485438) J Cell Sci. 2012 May 1;125(Pt 9):2134-40. (PMID: 22357956) Cell. 2009 May 29;137(5):926-37. (PMID: 19490897) J Cell Biol. 2011 Nov 28;195(5):799-813. (PMID: 22123864) Nat Rev Mol Cell Biol. 2011 Mar;12(3):163-76. (PMID: 21326200) J Cell Biol. 1999 Sep 20;146(6):1319-32. (PMID: 10491394) Nat Mater. 2010 Oct;9(10):827-32. (PMID: 20852617) J Biol Chem. 2001 Aug 24;276(34):32373-81. (PMID: 11423557) J Cell Biol. 1995 Oct;131(1):179-89. (PMID: 7559774) J Cell Biol. 1995 Nov;131(4):989-1002. (PMID: 7490299) J Biol Chem. 1995 May 12;270(19):11437-44. (PMID: 7744781) J Mol Biol. 2008 Jan 11;375(2):325-30. (PMID: 18021803) J Cell Biol. 1997 Mar 24;136(6):1287-305. (PMID: 9087444) J Biol Chem. 2004 Sep 10;279(37):38608-17. (PMID: 15247304) J Cell Biol. 2003 Mar 17;160(6):951-62. (PMID: 12642617) |
| معلومات مُعتمدة: | R01 GM097348 United States GM NIGMS NIH HHS; GM097348 United States GM NIGMS NIH HHS |
| المشرفين على المادة: | 0 (Actins) 0 (myosin VI) 9013-26-7 (Actomyosin) EC 3.6.1.- (Myosin Type II) EC 3.6.4.1 (Myosin Heavy Chains) |
| تواريخ الأحداث: | Date Created: 20120609 Date Completed: 20120626 Latest Revision: 20211021 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC3649007 |
| DOI: | 10.1126/science.1221708 |
| PMID: | 22679097 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1095-9203 |
|---|---|
| DOI: | 10.1126/science.1221708 |