دورية أكاديمية
أعرض في EDS

Effect of intermittent exposure to ethanol and MDMA during adolescence on learning and memory in adult mice.

التفاصيل البيبلوغرافية
العنوان: Effect of intermittent exposure to ethanol and MDMA during adolescence on learning and memory in adult mice.
المؤلفون: Vidal-Infer A; Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de Valencia, Avda, Blasco Ibáñez 21, 46010, Valencia, Spain., Aguilar MA, Miñarro J, Rodríguez-Arias M
المصدر: Behavioral and brain functions : BBF [Behav Brain Funct] 2012 Jun 20; Vol. 8, pp. 32. Date of Electronic Publication: 2012 Jun 20.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101245751 Publication Model: Electronic Cited Medium: Internet ISSN: 1744-9081 (Electronic) Linking ISSN: 17449081 NLM ISO Abbreviation: Behav Brain Funct Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2005-
مواضيع طبية MeSH: Ethanol/*pharmacology , Maze Learning/*drug effects , Memory/*drug effects , N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology , Serotonin Agents/*pharmacology, 3,4-Dihydroxyphenylacetic Acid/metabolism ; Animals ; Behavior, Animal/drug effects ; Corpus Striatum/drug effects ; Corpus Striatum/metabolism ; Dopamine/metabolism ; Hippocampus/drug effects ; Hippocampus/metabolism ; Hydroxyindoleacetic Acid/metabolism ; Male ; Mice ; Serotonin/metabolism
مستخلص: Background: Heavy binge drinking is increasingly frequent among adolescents, and consumption of 3,4-methylenedioxymethamphetamine (MDMA) is often combined with ethanol (EtOH). The long-lasting effects of intermittent exposure to EtOH and MDMA during adolescence on learning and memory were evaluated in adult mice using the Hebb-Williams maze.
Methods: Adolescent OF1 mice were exposed to EtOH (1.25 g/kg) on two consecutive days at 48-h intervals over a 14-day period (from PD 29 to 42). MDMA (10 or 20 mg/kg) was injected twice daily at 4-h intervals over two consecutive days, and this schedule was repeated six days later (PD 33, 34, 41 and 42), resulting in a total of eight injections. Animals were initiated in the Hebb-Williams maze on PND 64. The concentration of brain monoamines in the striatum and hippocampus was then measured.
Results: At the doses employed, both EtOH and MDMA, administered alone or together, impaired learning in the Hebb-Williams maze, as treated animals required more time to reach the goal than their saline-treated counterparts. The groups treated during adolescence with EtOH, alone or plus MDMA, also presented longer latency scores and needed more trials to reach the acquisition criterion score. MDMA induced a decrease in striatal DA concentration, an effect that was augmented by the co-administration of EtOH. All the treatment groups displayed an imbalance in the interaction DA/serotonin.
Conclusions: The present findings indicate that the developing brain is highly vulnerable to the damaging effects of EtOH and/or MDMA, since mice receiving these drugs in a binge pattern during adolescence exhibit impaired learning and memory in adulthood.
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المشرفين على المادة: 0 (Serotonin Agents)
102-32-9 (3,4-Dihydroxyphenylacetic Acid)
333DO1RDJY (Serotonin)
3K9958V90M (Ethanol)
54-16-0 (Hydroxyindoleacetic Acid)
KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
VTD58H1Z2X (Dopamine)
تواريخ الأحداث: Date Created: 20120622 Date Completed: 20130423 Latest Revision: 20211021
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC3542061
DOI: 10.1186/1744-9081-8-32
PMID: 22716128
قاعدة البيانات: MEDLINE
الوصف
تدمد:1744-9081
DOI:10.1186/1744-9081-8-32