دورية أكاديمية
Infiltrating CTLs are bothered by HLA-E on tumors.
| العنوان: | Infiltrating CTLs are bothered by HLA-E on tumors. |
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| المؤلفون: | Gooden MJ; Department of Obstetrics & Gynecology; University Medical Center Groningen; University of Groningen; Groningen, The Netherlands., van Hall T |
| المصدر: | Oncoimmunology [Oncoimmunology] 2012 Jan 01; Vol. 1 (1), pp. 92-93. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101570526 Publication Model: Print Cited Medium: Print ISSN: 2162-4011 (Print) Linking ISSN: 21624011 NLM ISO Abbreviation: Oncoimmunology Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Philadelphia, PA : Taylor & Francis Original Publication: Austin, TX : Landes Bioscience |
| مستخلص: | We recently described the upregulation of HLA-E in ovarian and cervical cancers. Instead of interacting with natural killer cells, HLA-E appeared to inhibit intratumoral cytotoxic T lymphocytes (CTL) via the receptor CD94/NKG2A. Strikingly, the survival benefit of intraepithelial infiltrating CTL was lost in those cancers with high HLA-E expression. |
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| تواريخ الأحداث: | Date Created: 20120622 Date Completed: 20210203 Latest Revision: 20211021 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC3376958 |
| DOI: | 10.4161/onci.1.1.17961 |
| PMID: | 22720221 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 2162-4011 |
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| DOI: | 10.4161/onci.1.1.17961 |