دورية أكاديمية
أعرض في EDS

Driving apoptosis-relevant proteins toward neural differentiation.

التفاصيل البيبلوغرافية
العنوان: Driving apoptosis-relevant proteins toward neural differentiation.
المؤلفون: Solá S; Research Institute for Medicines and Pharmaceutical Sciences, University of Lisbon, Lisbon, Portugal. susana.sola@ff.ul.pt, Aranha MM, Rodrigues CM
المصدر: Molecular neurobiology [Mol Neurobiol] 2012 Oct; Vol. 46 (2), pp. 316-31. Date of Electronic Publication: 2012 Jul 01.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Clifton, NJ : Humana Press, c1987-
مواضيع طبية MeSH: Cell Differentiation*, Apoptosis Regulatory Proteins/*metabolism , Neurons/*cytology , Neurons/*metabolism, Animals ; Caspases/metabolism ; Humans ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Tumor Suppressor Protein p53/metabolism
مستخلص: Emerging evidence suggests that apoptosis regulators and executioners may control cell fate, without involving cell death per se. Indeed, several conserved elements of apoptosis are integral components of terminal differentiation, which must be restrictively activated to assure differentiation efficiency, and carefully regulated to avoid cell loss. A better understanding of the molecular mechanisms underlying key checkpoints responsible for neural differentiation, as an alternative to cell death will surely make stem cells more suitable for neuro-replacement therapies. In this review, we summarize recent studies on the mechanisms underlying the non-apoptotic function of p53, caspases, and Bcl-2 family members during neural differentiation. In addition, we discuss how apoptosis-regulatory proteins control the decision between differentiation, self-renewal, and cell death in neural stem cells, and how activity is restrained to prevent cell loss.
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المشرفين على المادة: 0 (Apoptosis Regulatory Proteins)
0 (Proto-Oncogene Proteins c-bcl-2)
0 (Tumor Suppressor Protein p53)
EC 3.4.22.- (Caspases)
تواريخ الأحداث: Date Created: 20120704 Date Completed: 20130227 Latest Revision: 20211021
رمز التحديث: 20240628
DOI: 10.1007/s12035-012-8289-2
PMID: 22752662
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-1182
DOI:10.1007/s12035-012-8289-2