دورية أكاديمية
RARS with fibrosis and del(20q) transformed into ALL.
| العنوان: | RARS with fibrosis and del(20q) transformed into ALL. |
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| المؤلفون: | Rohr SS; Disciplina de Hematologia e Hemoterapia, UNIFESP-Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu, 740 -3.andar, São Paulo, SP, 04023-900, Brazil. sandra.rohr@gmail.com, Pelloso LA, Borgo Ados S, de Rezende JG Jr, Silva MR, Yamamoto M, de Lourdes L F Chauffaille M |
| المصدر: | Medical oncology (Northwood, London, England) [Med Oncol] 2012 Dec; Vol. 29 (5), pp. 3570-3. Date of Electronic Publication: 2012 Jul 04. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2011- : New York : Springer Original Publication: Northwood, Middlesex, England : Science and Technology Letters, c1994- |
| مواضيع طبية MeSH: | Anemia, Refractory/*pathology , Anemia, Sideroblastic/*pathology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/*pathology , Primary Myelofibrosis/*pathology, Aged ; Anemia, Refractory/genetics ; Anemia, Refractory/immunology ; Anemia, Sideroblastic/genetics ; Anemia, Sideroblastic/immunology ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/pathology ; Chromosome Deletion ; Chromosomes, Human, Pair 20/genetics ; Disease Progression ; Humans ; Immunophenotyping ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Primary Myelofibrosis/genetics ; Primary Myelofibrosis/immunology |
| مستخلص: | Transformation of myelodysplastic syndrome (MDS) into acute myelogenous leukemia occurs in approximately 30 % of cases, while progression into acute lymphoblastic leukemia (ALL) is rare. We report on a 67-year-old man with the diagnosis of MDS, subtype refractory anemia with ring sideroblasts (RARS), karyotype 20q- , JAK-2 negative and grade III fibrosis on the bone marrow biopsy, who evolved into ALL 33 months after the diagnosis of MDS. RARS is one of the subtypes of MDS with most indolent course. Deletion of the long arm of chromosome 20 (20q-) is considered as good prognosis by the International Prognostic Scoring System, an important scoring system for predicting survival and evolution of MDS. Primary MDS with bone marrow fibrosis may represent a distinct clinicopathological and is supposed to have an unfavorable prognosis. The combined analysis of these features makes this rare report still more challenging and illustrates that biology of MDS is yet to be discovered. |
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| تواريخ الأحداث: | Date Created: 20120705 Date Completed: 20130719 Latest Revision: 20211021 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s12032-012-0297-6 |
| PMID: | 22760793 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1559-131X |
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| DOI: | 10.1007/s12032-012-0297-6 |