دورية أكاديمية
Comparison of pulmonary complications after nonmyeloablative and conventional allogeneic hematopoietic cell transplant.
| العنوان: | Comparison of pulmonary complications after nonmyeloablative and conventional allogeneic hematopoietic cell transplant. |
|---|---|
| المؤلفون: | Diab KJ; Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Indiana University School of Medicine, Indianapolis, USA. kdiab@iupui.edu, Yu Z, Wood KL, Shmalo JA, Sheski FD, Farber MO, Wilkes DS, Nelson RP Jr |
| المصدر: | Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [Biol Blood Marrow Transplant] 2012 Dec; Vol. 18 (12), pp. 1827-34. Date of Electronic Publication: 2012 Jul 02. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Carden Jennings Publishing Country of Publication: United States NLM ID: 9600628 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-6536 (Electronic) Linking ISSN: 10838791 NLM ISO Abbreviation: Biol Blood Marrow Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Charlottesville, VA : Carden Jennings Publishing Original Publication: Charlottesville, VA : Kluge Carden Jennings Publishing, Co., Ltd., [1995- |
| مواضيع طبية MeSH: | Bronchiolitis Obliterans/*etiology , Hematopoietic Stem Cell Transplantation/*adverse effects , Hematopoietic Stem Cell Transplantation/*methods , Lung Diseases/*etiology , Transplantation Conditioning/*adverse effects , Transplantation Conditioning/*methods, Bronchiolitis Obliterans/pathology ; Case-Control Studies ; Cohort Studies ; Female ; Humans ; Incidence ; Kaplan-Meier Estimate ; Lung Diseases/pathology ; Male ; Middle Aged |
| مستخلص: | Nonmyeloablative conditioning before allogeneic hematopoietic cell transplant (HCT) is an alternative to conventional conditioning in older patients and those with comorbidities. It is not known whether the decreased tissue injury associated with nonmyeloablative conditioning lowers the risk of pulmonary complications. The medical records of patients who underwent transplantation were reviewed and all pulmonary complications documented. Sixty-two consecutive patients with hematologic malignancies who underwent minimally intensive HCT (subjects) were compared to 48 consecutive patients who received conventional myeloablative allogeneic peripheral blood HCT (controls) over the same period at Indiana University Hospital. Pulmonary complications were categorized according to the type of complication and the time of onset after transplantation. Median follow-up times were similar between groups (P = .70). The study population (minimal intensity recipients) was older (P < .01), and the incidence of chronic graft-versus-host disease (cGVHD) was higher in subjects than controls (P = .02). Sixty-nine percent of subjects and 73% of controls developed pulmonary complications (P = .70). There was a trend in the minimally conditioned patients towards a lower incidence of pulmonary complications in older patients in the early posttransplantation period and a higher incidence of infectious pneumonias and bronchiolitis obliterans syndrome at later time points. The frequency of pulmonary complications seems to be similar after minimally intensive or myeloablative conditioning and allotransplantation. There was no difference in overall mortality or pulmonary-related mortality between the 2 groups. (Copyright © 2012 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20120707 Date Completed: 20130709 Latest Revision: 20121113 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.bbmt.2012.06.013 |
| PMID: | 22766224 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1523-6536 |
|---|---|
| DOI: | 10.1016/j.bbmt.2012.06.013 |